Naslov
Novel vaginal drug delivery system : Deformable propylene glycol liposomes-in-hydrogel

Autori
Vanić, Željka ; Hurler, Julia ; Ferderber, Kristina ; Golja Gašparović, Petra ; Škalko-Basnet, Nataša ; Filipović-Grčić, Jelena

Izvornik
Journal of liposome research (0898-2104) 24 (2014), 1; 27-36

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
deformable liposomes; nanotechnology; propylene glycol; sustained release; vaginal delivery

Sažetak
Deformable propylene glycol-containing liposomes (DPGLs) incorporating metronidazole or clotrimazole were prepared and evaluated as an efficient drug delivery system to improve the treatment of vaginal microbial infections. The liposome formulations were optimized based on sufficient trapping efficiencies for both drugs and membrane elasticity as a prerequisite for successful permeability and therapy. An appropriate viscosity for vaginal administration was achieved by incorporating the liposomes into Carbopol hydrogel. DPGLs were able to penetrate through the hydrogel network more rapidly than conventional liposomes. In vitro studies of drug release from the liposomal hydrogel under conditions simulating human treatment confirmed sustained and diffusion-based drug release. Characterization of the rheological and textural properties of the DPGL-containing liposomal hydrogels demonstrated that the incorporation of DPGLs alone had no significant influence on mechanical properties of hydrogels compared to controls. These results support the great potential of DPGL-in-hydrogel as an efficient delivery system for the controlled and sustained release of antimicrobial drugs in the vagina.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA