Pregled bibliografske jedinice broj: 678240
NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology
NKT cell-TCR expression activates conventional T cells in vivo, but is largely dispensable for mature NKT cell biology // PLoS biology, 11 (2013), 6; e1001589-e1001589 doi:10.1371/journal.pbio.1001589 (međunarodna recenzija, članak, znanstveni)
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Naslov
NKT cell-TCR expression activates conventional T
cells in vivo, but is largely dispensable for
mature NKT cell biology
Autori
Vahl, J.C. ; Heger, K. ; Knies, N. ; Hein, M.Y. ; Boon, L. ; Yagita, H. ; Polić, Bojan ; Schmidt- Supprian, M.
Izvornik
PLoS biology (1544-9173) 11
(2013), 6;
E1001589-e1001589
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
NKT cells ; TCR ; survival
Sažetak
Natural killer T (NKT) cell development depends on recognition of self-glycolipids via their semi- invariant Vα14i-TCR. However, to what extent TCR- mediated signals determine identity and function of mature NKT cells remains incompletely understood. To address this issue, we developed a mouse strain allowing conditional Vα14i-TCR expression from within the endogenous Tcrα locus. We demonstrate that naïve T cells are activated upon replacement of their endogenous TCR repertoire with Vα14i-restricted TCRs, but they do not differentiate into NKT cells. On the other hand, induced TCR ablation on mature NKT cells did not affect their lineage identity, homeostasis, or innate rapid cytokine secretion abilities. We therefore propose that peripheral NKT cells become unresponsive to and thus are independent of their autoreactive TCR.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
