Naslov
Effect of Mycophenolate Mofetil Dose on Long-Term Kidney Allograft Function

Autori
Mihovilovic, Karlo ; Pavlovic, Matija ; Maksimovic, Bojana ; Knotek, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
J Am Soc Nephrol 24: 2013 / - , 2013

Skup
ASN 2013, Kidney Week

Mjesto i datum
Atlanta (GA), Sjedinjene Američke Države, 05.11.2013. - 10.11.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Kidney Allograft Function; Mycophenolate Mofetil Dose

Sažetak
Background: Studies have reported signifi cant improvement in kidney function in patients on MMF with lower exposition to calcineurin inhibitors.The optimal long-term MMF dosing in patients maintained on contemporary low-dose calcineurin inhibitors is still undetermined. The aim of our study was to determine effect of MMF dose on kidney function over fi ve years post-transplant. Methods: A cohort of 171 transplant patients with kidney, kidney- pancreas and kidney-liver transplantation was included. Immunosuppression consisted of anti- IL2 or antithymocyte immunoglobulin induction with MMF, calcineurin inhibitors ± steroids. Estimated creatinine clearence (eCrcl) was calculated using Cockroft Gault formula. MMF dose at 1, 2, 3, 4 and 5 years was correlated with eCrcl at respective time point. Univariate and multiple regression analyses were done to test relationship between independent variables and eCrcl. Data are shown as mean±SD, or median with range. Results: 105 patients had kidney transplantation and 58 kidney-pancreas transplantation. Recipients were a mean of 42.3 ± 12.03 years old at the time of transplantation, 63 percent of them were male and all were Caucasians. Donors were a mean of 42.8 ± 16.2 years old. There were 46 living donor transplantations. eCrcl at 1, 2, 3, 4 and 5 years post-transplant positively correlated with average MMF dose (p<0.01 for each time point). There was no correlation of eCrcl with tacrolimus or cyclosporin concentration at any time point. In multivariate analysis MMF dose remained strongly positively correlated with kidney function at all time points. Conclusions: Higher MMF dose with lower calcineurin concentration is associated with better long-term renal function and may increase long-term survival of transplanted kidney.

Izvorni jezik
Engleski

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