Pregled bibliografske jedinice broj: 678170
A dual function of NKG2D ligands in NK-cell activation
A dual function of NKG2D ligands in NK-cell activation // European journal of immunology, 42 (2012), 9; 2452-2458 doi:10.1002/eji.201141849 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 678170 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
A dual function of NKG2D ligands in NK-cell activation
Autori
Cheney, E.E. ; Wise, E.L. ; Bui, J.D. ; Schreiber, R.D. ; Carayannopoulos, L.N. ; Spitzer, D. ; Zafirova, Biljana ; Polić, Bojan ; Shaw, A.S. ; Markiewicz, M.A.
Izvornik
European journal of immunology (0014-2980) 42
(2012), 9;
2452-2458
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
NKG2D; NK cells; NKG2D ligands
Sažetak
NK-cell killing requires both the expression of activating receptor ligands and low MHC class I expression by target cells. Here we demonstrate that the expression of any of the murine ligands for the NK-cell activating receptor NKG2D results in a concomitant reduction in MHC class I expression. We show this both in tumor cell lines and in vivo. NK-cell lysis is enhanced by the decrease in MHC class I expression, suggesting the change is biologically relevant. These results demonstrate that NKG2D ligand expression on target cells not only allows for activating receptor recognition, but also actively reduces expression of the inhibitory ligand, MHC class I, leading to enhanced recognition and killing by NK cells.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0621261-1271 - Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava (Polić, Bojan, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
