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Pregled bibliografske jedinice broj: 678128

NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses

Zloza, Andrew; Kohlap, Frederick J.; Lyons, Gretchen E.; Scehnkel, Jason M.; Moore, Tamson V.; Lacek, Andrew T.; O'Sullivan, Jeremy A.; Varanasi, Vineeth; Williams, Jesse W.; Jagoda, Michael C. et al.
NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses // Nature medicine, 18 (2012), 3; 422-428 doi:10.1038/nm.2683 (međunarodna recenzija, članak, znanstveni)

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Naslov
NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses

Autori
Zloza, Andrew ; Kohlap, Frederick J. ; Lyons, Gretchen E. ; Scehnkel, Jason M. ; Moore, Tamson V. ; Lacek, Andrew T. ; O'Sullivan, Jeremy A. ; Varanasi, Vineeth ; Williams, Jesse W. ; Jagoda, Michael C. ; Bellavance, Emily C. ; Marzo, Amanda L. ; Thomas, Paul G. ; Zafirova, Biljana ; Polić, Bojan ; Al-Harthi, Lena ; Sperling, Anne I. ; Guevara-Patiño, José A.

Izvornik
Nature medicine (1078-8956) 18 (2012), 3; 422-428

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NKG2D; CD8 T cell memory; vacine

Sažetak
CD4-unhelped CD8+ T cells are functionally defective T cells primed in the absence of CD4+ T cell help. Given the co-stimulatory role of natural-killer group 2, member D protein (NKG2D) on CD8+ T cells, we investigated its ability to rescue these immunologically impotent cells. We demonstrate that augmented co-stimulation through NKG2D during priming paradoxically rescues memory, but not effector, CD8+ T cell responses. NKG2D-mediated rescue is characterized by reversal of elevated transcription factor T-box expressed in T cells (T-bet) expression and recovery of interleukin-2 and interferon-g production and cytolytic responses. Rescue is abrogated in CD8+ T cells lacking NKG2D. Augmented co-stimulation through NKG2D confers a high rate of survival to mice lacking CD4+ T cells in a CD4-dependent influenza model and rescues HIV-specific CD8+ T cell responses from CD4-deficient HIV-positive donors. These findings demonstrate that augmented co-stimulation through NKG2D is effective in rescuing CD4-unhelped CD8+ T cells from their pathophysiological fate and may provide therapeutic benefits.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0621261-1271 - Uloga NKG2D u razvoju, homeostazi i efektorskim funkcijama imunološkog sustava (Polić, Bojan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Biljana Zafirova (autor)

Avatar Url Bojan Polić (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.ncbi.nlm.nih.gov www.nature.com

Citiraj ovu publikaciju:

Zloza, Andrew; Kohlap, Frederick J.; Lyons, Gretchen E.; Scehnkel, Jason M.; Moore, Tamson V.; Lacek, Andrew T.; O'Sullivan, Jeremy A.; Varanasi, Vineeth; Williams, Jesse W.; Jagoda, Michael C. et al.
NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses // Nature medicine, 18 (2012), 3; 422-428 doi:10.1038/nm.2683 (međunarodna recenzija, članak, znanstveni)
Zloza, A., Kohlap, F., Lyons, G., Scehnkel, J., Moore, T., Lacek, A., O'Sullivan, J., Varanasi, V., Williams, J. & Jagoda, M. (2012) NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses. Nature medicine, 18 (3), 422-428 doi:10.1038/nm.2683.
@article{article, author = {Zloza, Andrew and Kohlap, Frederick J. and Lyons, Gretchen E. and Scehnkel, Jason M. and Moore, Tamson V. and Lacek, Andrew T. and O'Sullivan, Jeremy A. and Varanasi, Vineeth and Williams, Jesse W. and Jagoda, Michael C. and Bellavance, Emily C. and Marzo, Amanda L. and Thomas, Paul G. and Zafirova, Biljana and Poli\'{c}, Bojan and Al-Harthi, Lena and Sperling, Anne I. and Guevara-Pati\~{n}o, Jos\'{e} A.}, year = {2012}, pages = {422-428}, DOI = {10.1038/nm.2683}, keywords = {NKG2D, CD8 T cell memory, vacine}, journal = {Nature medicine}, doi = {10.1038/nm.2683}, volume = {18}, number = {3}, issn = {1078-8956}, title = {NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses}, keyword = {NKG2D, CD8 T cell memory, vacine} }
@article{article, author = {Zloza, Andrew and Kohlap, Frederick J. and Lyons, Gretchen E. and Scehnkel, Jason M. and Moore, Tamson V. and Lacek, Andrew T. and O'Sullivan, Jeremy A. and Varanasi, Vineeth and Williams, Jesse W. and Jagoda, Michael C. and Bellavance, Emily C. and Marzo, Amanda L. and Thomas, Paul G. and Zafirova, Biljana and Poli\'{c}, Bojan and Al-Harthi, Lena and Sperling, Anne I. and Guevara-Pati\~{n}o, Jos\'{e} A.}, year = {2012}, pages = {422-428}, DOI = {10.1038/nm.2683}, keywords = {NKG2D, CD8 T cell memory, vacine}, journal = {Nature medicine}, doi = {10.1038/nm.2683}, volume = {18}, number = {3}, issn = {1078-8956}, title = {NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses}, keyword = {NKG2D, CD8 T cell memory, vacine} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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