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Pregled bibliografske jedinice broj: 676990

Flavonoid aglycones can compete with Ochratoxin A for human serum albumin : a new possible mode of action

Poór, Miklós; Kunsági-Máté, Sándor; Bencsik, Tímea; Petrik, Jozsef; Vladimir-Knežević, Sanda; Kőszegi, Tamás
Flavonoid aglycones can compete with Ochratoxin A for human serum albumin : a new possible mode of action // International journal of biological macromolecules, 51 (2012), 3; 279-283 doi:10.1016/j.ijbiomac.2012.05.019 (međunarodna recenzija, članak, znanstveni)

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Naslov
Flavonoid aglycones can compete with Ochratoxin A for human serum albumin : a new possible mode of action

Autori
Poór, Miklós ; Kunsági-Máté, Sándor ; Bencsik, Tímea ; Petrik, Jozsef ; Vladimir-Knežević, Sanda ; Kőszegi, Tamás

Izvornik
International journal of biological macromolecules (0141-8130) 51 (2012), 3; 279-283

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
flavonoids; Ochratoxin A; Competitive interaction; Human serum albumin; Fluorescence polarization

Sažetak
The mycotoxin Ochratoxin A (OTA) appears worldwide in cereals, plant products, different foods and drinks. Ochratoxin A binds to plasma albumin with a very high affinity. However, it is well known that natural flavonoids can also bind to human serum albumin (HSA) at the same binding site as OTA does (site I, subdomain IIA). A few experimental literature data suggest that reducing the bound fraction of OTA speeds up its elimination rate with a potential decrease in its toxicity. In our experimental model competitive binding properties of flavonoid aglycones were examined with a fluorescence polarization based approach. Our data show that some of the flavonoids are able to remove the toxin from HSA. We conclude that among the 13 studied flavonoid aglycones galangin and quercetin were the most effective competitors for OTA.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA

Projekti:
006-0061117-1238 - Bioaktivne prirodne tvari: izolacija, karakterizacija i biološki učinci (Vladimir-Knežević, Sanda, MZOS ) ( CroRIS)
006-1340227-1248 - Endotelinski sustav i antioksidansi u zloćudnim tumorima (Petrik, Jozsef, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Jozsef Petrik (autor)

Avatar Url Sanda Vladimir-Knežević (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Poór, Miklós; Kunsági-Máté, Sándor; Bencsik, Tímea; Petrik, Jozsef; Vladimir-Knežević, Sanda; Kőszegi, Tamás
Flavonoid aglycones can compete with Ochratoxin A for human serum albumin : a new possible mode of action // International journal of biological macromolecules, 51 (2012), 3; 279-283 doi:10.1016/j.ijbiomac.2012.05.019 (međunarodna recenzija, članak, znanstveni)
Poór, M., Kunsági-Máté, S., Bencsik, T., Petrik, J., Vladimir-Knežević, S. & Kőszegi, T. (2012) Flavonoid aglycones can compete with Ochratoxin A for human serum albumin : a new possible mode of action. International journal of biological macromolecules, 51 (3), 279-283 doi:10.1016/j.ijbiomac.2012.05.019.
@article{article, author = {Po\'{o}r, Mikl\'{o}s and Kuns\'{a}gi-M\'{a}t\'{e}, S\'{a}ndor and Bencsik, T\'{\i}mea and Petrik, Jozsef and Vladimir-Kne\v{z}evi\'{c}, Sanda and K\H{o}szegi, Tam\'{a}s}, year = {2012}, pages = {279-283}, DOI = {10.1016/j.ijbiomac.2012.05.019}, keywords = {flavonoids, Ochratoxin A, Competitive interaction, Human serum albumin, Fluorescence polarization}, journal = {International journal of biological macromolecules}, doi = {10.1016/j.ijbiomac.2012.05.019}, volume = {51}, number = {3}, issn = {0141-8130}, title = {Flavonoid aglycones can compete with Ochratoxin A for human serum albumin : a new possible mode of action}, keyword = {flavonoids, Ochratoxin A, Competitive interaction, Human serum albumin, Fluorescence polarization} }
@article{article, author = {Po\'{o}r, Mikl\'{o}s and Kuns\'{a}gi-M\'{a}t\'{e}, S\'{a}ndor and Bencsik, T\'{\i}mea and Petrik, Jozsef and Vladimir-Kne\v{z}evi\'{c}, Sanda and K\H{o}szegi, Tam\'{a}s}, year = {2012}, pages = {279-283}, DOI = {10.1016/j.ijbiomac.2012.05.019}, keywords = {flavonoids, Ochratoxin A, Competitive interaction, Human serum albumin, Fluorescence polarization}, journal = {International journal of biological macromolecules}, doi = {10.1016/j.ijbiomac.2012.05.019}, volume = {51}, number = {3}, issn = {0141-8130}, title = {Flavonoid aglycones can compete with Ochratoxin A for human serum albumin : a new possible mode of action}, keyword = {flavonoids, Ochratoxin A, Competitive interaction, Human serum albumin, Fluorescence polarization} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • EMBASE (Excerpta Medica)
  • MEDLINE

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