Naslov
Glomerulonephritis after renal transplantation

Autori
Bacalja, Jasna ; Bulimbašić, Stela ; Pačić, Arijana ; Mihovilović, Karlo ; Šenjug, Petar ; Knotek, Mladen ; Galešić Ljubanović, Danica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
24nd LJudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 31.05.2013. - 01.06.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Glomerulonephritis; renal transplantation

Sažetak
Glomerulonephritis (GN) after renal transplantation can be caused by recurrent disease, development of de novo GN in the transplanted organ, or transplanted GN from a donor with unrecognized disease. It is an underlying cause of end-stage renal failure in 30%-50% of kidney transplant recipients. We analyzed clinical data and histopathologic findings of patients who had biopsy proven glomerulonephritis after renal transplantation diagnosed at Department of Pathology, Dubrava University Hospital. Clinicopathologic data of six patients with biopsy proven GN after renal transplantation were collected to assess the prevalence, clinical course and outcome of the disease. Five males and one female (age range 29- 47, mean 37.6 years) had biopsy proven GN, diagnosed 6-525 days after transplantation. Four patients presented with abnormal and two with normal clinical and laboratory data. Focal segmental glomerulosclerosis (FSGS) was diagnosed in three patients. IgA nephropathy, membranoproliferative GN type I and pauci-immune GN (PI-GN) were diagnosed in one patient each. Five patients had recurrence of primary disease (3 patients with FSGS, one membranoproliferative GN and one PI-GN). IgA nephropathy developed de novo in a patient with autosomal dominant polycystic kidney disease. At the end of follow up (1.5-7 years after transplantation), three patients were on chronic dialysis, two had normal and one abnormal graft function. In conclusion, in our study FSGS was the most common GN after transplantation. The graft loss in our transplant patients with GN was 50%.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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