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Pregled bibliografske jedinice broj: 674625

Systematic review of purine analog treatment for chronic lymphocytic leukemia : lessons for future trials

Bauduer, M.; Gribben, J.; Herrmann, R.; Thiel, E.; Rai, K.; Larson, R.; Ferrara, F.; Barnard, J.; Pearce, H.; Taylor, C. et al.
Systematic review of purine analog treatment for chronic lymphocytic leukemia : lessons for future trials // Haematologica, 97 (2012), 3; 428-436 doi:10.3324/haematol.2011.053512 (međunarodna recenzija, članak, znanstveni)

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Naslov
Systematic review of purine analog treatment for chronic lymphocytic leukemia : lessons for future trials
(Systematic review of purine analog treatment for chronic lymphocytic leukemia: lessons for future trials)

Autori
Bauduer, M. ; Gribben, J. ; Herrmann, R. ; Thiel, E. ; Rai, K. ; Larson, R. ; Ferrara, F. ; Barnard, J. ; Pearce, H. ; Taylor, C. ; Brillant, B. ; Steurer, M. ; Weingart, O. ; Flinn, W. ; Funkhouser, A. ; Nallman, M. ; Sun, Z. ; Jakšić, Branimir ; Suciou, S. ; Chevret, S. ; Dighiero, G. ; Leporrier, M. ; Frankel, S.R. ; Sirard, C. ; Hillmen, P. ; Trehu, B. ; Felder, M. ; Busch, R. ; Eichorst, B. ; Mallek, M. ; Stilgenbauer, S. ; Pangalis, G. ; Bezares, R. ; van Oers, M.H.J. ; van Putten, W. ; Gobbi, M. ; Spriano, M. ; Mabed, M. ; Catovsky, D. ; Richards, S. ; Wade, R. ; Abdelhamid, T. ; Dearden, C. ; Knauf, W. ; Blonski, J. ; Jamroziak, K. ; Robak, T. ; Mauro, F. ; Hiddeman, W. ; Johnson, S.A. ; Longthorne, G. ; Rummel, M.J. ; Juliusson, G. ; Pulluqui, P. ; Zinzani, P.L. ; Pozzato, G. ; Reynolds, C ; Furman, R.R. ; Durrant, J. ; Elphinstone, P. ; Evans, V. ; Gettins, .L ; Hicks, C. ; James, S. ; Clarke, M. ; MacKinnon, L. ; McHugh, T.M. ; Morris, P. ; Read, S. ; Gregory, C.

Izvornik
Haematologica (0390-6078) 97 (2012), 3; 428-436

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
purine analog; combination therapy; CLL; review; cyclophosphamide

Sažetak
A systematic review of purine analogs revealed heterogeneity between trials in treatment effects on response and progression free survival, but not survival, perhaps partly due to variations in analytical methods. In addition, combination treatments required evaluation. Therefore, individual patient data were sought for all randomized trials in untreated chronic lymphocytic leukemia which involved a purine analog, but which did not include antibody therapies. Sixteen trials were found, addressing seven comparisons. Eight trials, with 2, 753 patients, showed that single agent purine analog improved progression free survival (odds ratio=0.71 ; 95% confidence interval=0.63-0.79). Heterogeneity remained substantial. Three trials, with 1, 403 patients, showed that progression free survival was further improved by the addition of cyclophosphamide (odds ratio=0.54 ; 0.47-0.62). Fewer data were available on the addition of other drugs to purine analog, and none showed clear benefit. Two trials, with 544 patients, suggested cladribine improved progression free survival compared to fludarabine (odds ratio=0.77 ; 0.63-0.95). No differences were seen in overall survival for any comparisons. In conclusion, purine analogs, particularly combined with cyclophosphamide, significantly improve progression free survival but not survival. Some groups, such as the elderly, may not see the same benefits and maximizing doses may be important for all treatments, including chlorambucil. Longer follow up, consistent definitions and detailed reporting of trials should be encouraged.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081873-1893 - Prognostički faktori, dijagnostika i terapija hemoblastoza (Jakšić, Branimir, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Branimir Jakšić (autor)

Poveznice na cjeloviti tekst rada:

doi www.haematologica.org

Citiraj ovu publikaciju:

Bauduer, M.; Gribben, J.; Herrmann, R.; Thiel, E.; Rai, K.; Larson, R.; Ferrara, F.; Barnard, J.; Pearce, H.; Taylor, C. et al.
Systematic review of purine analog treatment for chronic lymphocytic leukemia : lessons for future trials // Haematologica, 97 (2012), 3; 428-436 doi:10.3324/haematol.2011.053512 (međunarodna recenzija, članak, znanstveni)
Bauduer, M., Gribben, J., Herrmann, R., Thiel, E., Rai, K., Larson, R., Ferrara, F., Barnard, J., Pearce, H. & Taylor, C. (2012) Systematic review of purine analog treatment for chronic lymphocytic leukemia : lessons for future trials. Haematologica, 97 (3), 428-436 doi:10.3324/haematol.2011.053512.
@article{article, author = {Bauduer, M. and Gribben, J. and Herrmann, R. and Thiel, E. and Rai, K. and Larson, R. and Ferrara, F. and Barnard, J. and Pearce, H. and Taylor, C. and Brillant, B. and Steurer, M. and Weingart, O. and Flinn, W. and Funkhouser, A. and Nallman, M. and Sun, Z. and Jak\v{s}i\'{c}, Branimir and Suciou, S. and Chevret, S. and Dighiero, G. and Leporrier, M. and Frankel, S.R. and Sirard, C. and Hillmen, P. and Trehu, B. and Felder, M. and Busch, R. and Eichorst, B. and Mallek, M. and Stilgenbauer, S. and Pangalis, G. and Bezares, R. and van Oers, M.H.J. and van Putten, W. and Gobbi, M. and Spriano, M. and Mabed, M. and Catovsky, D. and Richards, S. and Wade, R. and Abdelhamid, T. and Dearden, C. and Knauf, W. and Blonski, J. and Jamroziak, K. and Robak, T. and Mauro, F. and Hiddeman, W. and Johnson, S.A. and Longthorne, G. and Rummel, M.J. and Juliusson, G. and Pulluqui, P. and Zinzani, P.L. and Pozzato, G. and Reynolds, C and Furman, R.R. and Durrant, J. and Elphinstone, P. and Evans, V. and Gettins, .L and Hicks, C. and James, S. and Clarke, M. and MacKinnon, L. and McHugh, T.M. and Morris, P. and Read, S. and Gregory, C.}, year = {2012}, pages = {428-436}, DOI = {10.3324/haematol.2011.053512}, keywords = {purine analog, combination therapy, CLL, review, cyclophosphamide}, journal = {Haematologica}, doi = {10.3324/haematol.2011.053512}, volume = {97}, number = {3}, issn = {0390-6078}, title = {Systematic review of purine analog treatment for chronic lymphocytic leukemia : lessons for future trials}, keyword = {purine analog, combination therapy, CLL, review, cyclophosphamide} }
@article{article, author = {Bauduer, M. and Gribben, J. and Herrmann, R. and Thiel, E. and Rai, K. and Larson, R. and Ferrara, F. and Barnard, J. and Pearce, H. and Taylor, C. and Brillant, B. and Steurer, M. and Weingart, O. and Flinn, W. and Funkhouser, A. and Nallman, M. and Sun, Z. and Jak\v{s}i\'{c}, Branimir and Suciou, S. and Chevret, S. and Dighiero, G. and Leporrier, M. and Frankel, S.R. and Sirard, C. and Hillmen, P. and Trehu, B. and Felder, M. and Busch, R. and Eichorst, B. and Mallek, M. and Stilgenbauer, S. and Pangalis, G. and Bezares, R. and van Oers, M.H.J. and van Putten, W. and Gobbi, M. and Spriano, M. and Mabed, M. and Catovsky, D. and Richards, S. and Wade, R. and Abdelhamid, T. and Dearden, C. and Knauf, W. and Blonski, J. and Jamroziak, K. and Robak, T. and Mauro, F. and Hiddeman, W. and Johnson, S.A. and Longthorne, G. and Rummel, M.J. and Juliusson, G. and Pulluqui, P. and Zinzani, P.L. and Pozzato, G. and Reynolds, C and Furman, R.R. and Durrant, J. and Elphinstone, P. and Evans, V. and Gettins, .L and Hicks, C. and James, S. and Clarke, M. and MacKinnon, L. and McHugh, T.M. and Morris, P. and Read, S. and Gregory, C.}, year = {2012}, pages = {428-436}, DOI = {10.3324/haematol.2011.053512}, keywords = {purine analog, combination therapy, CLL, review, cyclophosphamide}, journal = {Haematologica}, doi = {10.3324/haematol.2011.053512}, volume = {97}, number = {3}, issn = {0390-6078}, title = {Systematic review of purine analog treatment for chronic lymphocytic leukemia: lessons for future trials}, keyword = {purine analog, combination therapy, CLL, review, cyclophosphamide} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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