Naslov
Liječenje Langerhansove histiocitoze u djece
(Treatment of langerhans cell histiocytosis in children)

Autori
Bilić, Ernest ; Bojanić, Katarina ; Dapić, Tomislav ; Femenić, Ranka ; Husar, Karmela ; Konja, Josip ; Murat-Susić, slobodna ; Pavlović, Maja ; Potocki, Kristina ; Antabak, Anko ; Anticević, Darko ; Rajić, Ljubica

Izvornik
Liječnički vjesnik (0024-3477) 11-12 (2011); 376-384

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, stručni

Ključne riječi
histiocitoza kod djece
(histiocytosis in children)

Sažetak
Langerhans' cell histiocytosis (LCH) is a disease characterised by pathologic accumulation and proliferation of histiocytes, cells from the monocyte-macrophage system, in various tissues and organs. In this retrospective study we analyzed patients charts treated in the Department of pediatric hematology and oncology at the University Hospital Zagreb with the diagnosis of LCH. Twenty-two children were diagnosed between January 1st 1996 and December 31st 2010, and all were treated with chemotherapy. 19 patients survived (86%) and the remaining 3 (14%), all under the age of 2 with multisystem disease, died. At the time of diagnosis 12 children (55%) presented with single-system disease, the most common were bone lesions in 8 children (36%). All children were treated according to protocols LCH-I and LCH -III. Eight children had mild complications of treatment and the disease itself. Diabetes insipidus remains in 4 children.

Izvorni jezik
Hrvatski

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