Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 673862

Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice

Silva, Carla G.; Métin, Christine; Fazeli, Walid; Machado, Nuno J.; Darmopil, Sanja; Launay, Pierre-Serge; Ghestem, Antoine; Nesa, Marie-Pascale; Bassot, Emilie; Szabó, Eszter et al.
Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice // Science Translational Medicine, 5 (2013), 195ra; 104-1 doi:10.1126/scitranslmed.3006258 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 673862 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice

Autori
Silva, Carla G. ; Métin, Christine ; Fazeli, Walid ; Machado, Nuno J. ; Darmopil, Sanja ; Launay, Pierre-Serge ; Ghestem, Antoine ; Nesa, Marie-Pascale ; Bassot, Emilie ; Szabó, Eszter ; Baqi, Younis ; Müller, Christa E ; Tomé, Angelo R ; Ivanov, Anton ; Isbrandt, Dirk ; Zilberter, Yuri ; . Cunha, Rodrigo A ; Esclapez, Monique ; Bernard, Christophe

Izvornik
Science Translational Medicine (1946-6234) 5 (2013), 195ra; 104-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adenosine receptors antagonist; caffeine; rodents; neural development

Sažetak
Consumption of certain substances during pregnancy can interfere with brain development, leading to deleterious long-term neurological and cognitive impairments in offspring. To test whether modulators of adenosine receptors affect neural development, we exposed mouse dams to a subtype-selective adenosine type 2A receptor (A2AR) antagonist or to caffeine, a naturally occurring adenosine receptor antagonist, during pregnancy and lactation. We observed delayed migration and insertion of γ-aminobutyric acid (GABA) neurons into the hippocampal circuitry during the first postnatal week in offspring of dams treated with the A2AR antagonist or caffeine. This was associated with increased neuronal network excitability and increased susceptibility to seizures in response to a seizure-inducing agent. Adult offspring of mouse dams exposed to A2AR antagonists during pregnancy and lactation displayed loss of hippocampal GABA neurons and some cognitive deficits. These results demonstrate that exposure to A2AR antagonists including caffeine during pregnancy and lactation in rodents may have adverse effects on the neural development of their offspring.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081870-1932 - PUTEVI MIGRACIJE HIPOKAMPALNIH GABA-ergičkih NEURONA U MAJMUNA I ČOVJEKA (Petanjek, Zdravko, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Sanja Darmopil (autor)

Poveznice na cjeloviti tekst rada:

doi stm.sciencemag.org

Citiraj ovu publikaciju:

Silva, Carla G.; Métin, Christine; Fazeli, Walid; Machado, Nuno J.; Darmopil, Sanja; Launay, Pierre-Serge; Ghestem, Antoine; Nesa, Marie-Pascale; Bassot, Emilie; Szabó, Eszter et al.
Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice // Science Translational Medicine, 5 (2013), 195ra; 104-1 doi:10.1126/scitranslmed.3006258 (međunarodna recenzija, članak, znanstveni)
Silva, C., Métin, C., Fazeli, W., Machado, N., Darmopil, S., Launay, P., Ghestem, A., Nesa, M., Bassot, E. & Szabó, E. (2013) Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice. Science Translational Medicine, 5 (195ra), 104-1 doi:10.1126/scitranslmed.3006258.
@article{article, author = {Silva, Carla G. and M\'{e}tin, Christine and Fazeli, Walid and Machado, Nuno J. and Darmopil, Sanja and Launay, Pierre-Serge and Ghestem, Antoine and Nesa, Marie-Pascale and Bassot, Emilie and Szab\'{o}, Eszter and Baqi, Younis and M\"{u}ller, Christa E and Tom\'{e}, Angelo R and Ivanov, Anton and Isbrandt, Dirk and Zilberter, Yuri and . Cunha, Rodrigo A and Esclapez, Monique and Bernard, Christophe}, year = {2013}, pages = {104-1-104-12}, DOI = {10.1126/scitranslmed.3006258}, keywords = {adenosine receptors antagonist, caffeine, rodents, neural development}, journal = {Science Translational Medicine}, doi = {10.1126/scitranslmed.3006258}, volume = {5}, number = {195ra}, issn = {1946-6234}, title = {Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice}, keyword = {adenosine receptors antagonist, caffeine, rodents, neural development} }
@article{article, author = {Silva, Carla G. and M\'{e}tin, Christine and Fazeli, Walid and Machado, Nuno J. and Darmopil, Sanja and Launay, Pierre-Serge and Ghestem, Antoine and Nesa, Marie-Pascale and Bassot, Emilie and Szab\'{o}, Eszter and Baqi, Younis and M\"{u}ller, Christa E and Tom\'{e}, Angelo R and Ivanov, Anton and Isbrandt, Dirk and Zilberter, Yuri and . Cunha, Rodrigo A and Esclapez, Monique and Bernard, Christophe}, year = {2013}, pages = {104-1-104-12}, DOI = {10.1126/scitranslmed.3006258}, keywords = {adenosine receptors antagonist, caffeine, rodents, neural development}, journal = {Science Translational Medicine}, doi = {10.1126/scitranslmed.3006258}, volume = {5}, number = {195ra}, issn = {1946-6234}, title = {Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice}, keyword = {adenosine receptors antagonist, caffeine, rodents, neural development} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.