Naslov
Glukoza smanjuje poremećaje nocicepcije uzrokovane aloksanom
(Glucose reduces alloxan induced alterations of nociception)

Autori
Šalković-Petrišić, Melita ; Lacković, Zdravko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Fundamental and clinical pharmacology / Giudicelli, Jean-Francois - Pariz : Elsevier, 1999

Skup
Second European Congress of Pharmacology

Mjesto i datum
Budimpešta, Mađarska, 03.07.1999. - 07.07.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
glukoza; aloksan; nocicepcija; intracerebroventrikularno
(glucose; alloxan; nociception; intrcerebroventricular)

Sažetak
GLUCOSE REDUCES ALLOXAN INDUCED ALTERATIONS OF NOCICEPTION M. Šalković-Petrišić, Z. Lacković Laboratory of Molecular Neuropharmacology, Department of Pharmacology & Croatian Brain Research Institute, Medical School, University of Zagreb, Šalata 11, HR 10 000 Zagreb, Croatia According to literature data, alloxan-induced betacytotoxic effects can be prevented by prior glucose administration. We investigated the effects of peripheral (intraperiotoneal /ip/) and central (intracerebroventricular /icv/) 0.1M and 1M glucose-15 min pretreatment on centrally (icv) applied alloxan (1000 mg/kg) -induced alterations of nociception, determined by the "hot plate" and the "tail immersion" tests. Alloxan icv treatment alone induced gradual increase (Ł100% over control) of pain treshold in both tests in the course of a 3 week posttreatment period. Similar increament of pain treshold was induced by a glucose (ip/icv) treatment alone, as well. Glucose pretreatment, in general, reduced alloxan induced increase of pain treshlod in both tests. However, the effect was more consistent, pronounced with higher glucose dose (in the hot test plate even reversed to control values) and could be seen as early as 1 week following glucose icv (vs. 3 weeks following glucose ip pretreatment). It seems that glucose 15 min-pretreatment reduces alloxan icv-induced alterations of pain treshlod, with glucose icv pretreatment being more successful than glucose ip pretreatment. Supported by The Ministry of Science of Republic of Croatia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA