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Pregled bibliografske jedinice broj: 671552

Spatio-temporal transcriptome of the human brain

Kang, Hyojong; Kawasawa, Yuka; Cheng, Feng; Zhu, Ying; Xu, Xuming; Li, Mingfeng; Sousa, Andre; Pletikos, Mihovil; Meyer, Kyle; Sedmak, Goran et al.
Spatio-temporal transcriptome of the human brain // Nature, 478 (2011), 7670; 483-489 doi:10.1038/nature10523 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 671552 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Spatio-temporal transcriptome of the human brain

Autori
Kang, Hyojong ; Kawasawa, Yuka ; Cheng, Feng ; Zhu, Ying ; Xu, Xuming ; Li, Mingfeng ; Sousa, Andre ; Pletikos, Mihovil ; Meyer, Kyle ; Sedmak, Goran ; Guennel, Tobias ; Snin, Yure ; Johnson, Matthew ; Krnik, Željka ; Mayer, Simone ; Fertuzinhos, Sofia ; Umlauf, S. ; Lisgo, S.N. ; Vortmeyer, Anita ; Weinberger, Daniel ; Mane, Srikant ; Hyde, Tom ; Huttner, Anita ; Reimers, Mark ; Kleimann, Joel ; Šestan, Nenad

Izvornik
Nature (0028-0836) 478 (2011), 7670; 483-489

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
gene expression; brain development; microarray; human brain

Sažetak
Brain development and function depend on the precise regulation of gene expression. However, our understanding of the complexity and dynamics of the transcriptome of the human brain is incomplete. Here we report the generation and analysis of exon-level transcriptome and associated genotyping data, representing males and females of different ethnicities, from multiple brain regions and neocortical areas of developing and adult post-mortem human brains. We found that 86 per cent of the genes analysed were expressed, and that 90 per cent of these were differentially regulated at the whole-transcript or exon level across brain regions and/or time. The majority of these spatio-temporal differences were detected before birth, with subsequent increases in the similarity among regional transcriptomes. The transcriptome is organized into distinct co- expression networks, and shows sex-biased gene expression and exon usage. We also profiled trajectories of genes associated with neurobiological categories and diseases, and identified associations between single nucleotide polymorphisms and gene expression. This study provides a comprehensive data set on the human brain transcriptome and insights into the transcriptional foundations of human neurodevelopment.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081870-1878 - Uloga prolaznih fetalnih neurona u razvojnim poremećajima moždane kore (Judaš, Miloš, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Mihovil Pletikos (autor)

Avatar Url Goran Sedmak (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Kang, Hyojong; Kawasawa, Yuka; Cheng, Feng; Zhu, Ying; Xu, Xuming; Li, Mingfeng; Sousa, Andre; Pletikos, Mihovil; Meyer, Kyle; Sedmak, Goran et al.
Spatio-temporal transcriptome of the human brain // Nature, 478 (2011), 7670; 483-489 doi:10.1038/nature10523 (međunarodna recenzija, članak, znanstveni)
Kang, H., Kawasawa, Y., Cheng, F., Zhu, Y., Xu, X., Li, M., Sousa, A., Pletikos, M., Meyer, K. & Sedmak, G. (2011) Spatio-temporal transcriptome of the human brain. Nature, 478 (7670), 483-489 doi:10.1038/nature10523.
@article{article, author = {Kang, Hyojong and Kawasawa, Yuka and Cheng, Feng and Zhu, Ying and Xu, Xuming and Li, Mingfeng and Sousa, Andre and Pletikos, Mihovil and Meyer, Kyle and Sedmak, Goran and Guennel, Tobias and Snin, Yure and Johnson, Matthew and Krnik, \v{Z}eljka and Mayer, Simone and Fertuzinhos, Sofia and Umlauf, S. and Lisgo, S.N. and Vortmeyer, Anita and Weinberger, Daniel and Mane, Srikant and Hyde, Tom and Huttner, Anita and Reimers, Mark and Kleimann, Joel and \v{S}estan, Nenad}, year = {2011}, pages = {483-489}, DOI = {10.1038/nature10523}, keywords = {gene expression, brain development, microarray, human brain}, journal = {Nature}, doi = {10.1038/nature10523}, volume = {478}, number = {7670}, issn = {0028-0836}, title = {Spatio-temporal transcriptome of the human brain}, keyword = {gene expression, brain development, microarray, human brain} }
@article{article, author = {Kang, Hyojong and Kawasawa, Yuka and Cheng, Feng and Zhu, Ying and Xu, Xuming and Li, Mingfeng and Sousa, Andre and Pletikos, Mihovil and Meyer, Kyle and Sedmak, Goran and Guennel, Tobias and Snin, Yure and Johnson, Matthew and Krnik, \v{Z}eljka and Mayer, Simone and Fertuzinhos, Sofia and Umlauf, S. and Lisgo, S.N. and Vortmeyer, Anita and Weinberger, Daniel and Mane, Srikant and Hyde, Tom and Huttner, Anita and Reimers, Mark and Kleimann, Joel and \v{S}estan, Nenad}, year = {2011}, pages = {483-489}, DOI = {10.1038/nature10523}, keywords = {gene expression, brain development, microarray, human brain}, journal = {Nature}, doi = {10.1038/nature10523}, volume = {478}, number = {7670}, issn = {0028-0836}, title = {Spatio-temporal transcriptome of the human brain}, keyword = {gene expression, brain development, microarray, human brain} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • MEDLINE

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