Pregled bibliografske jedinice broj: 671344
Potential Coupling of Chemical and Conformational Changes in Pyruvate Formate-Lyase During the Catalysis
Potential Coupling of Chemical and Conformational Changes in Pyruvate Formate-Lyase During the Catalysis // Summer School "Fundamental Problems in Statistical Physics"
Leuven, Belgija, 2013. (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 671344 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Potential Coupling of Chemical and Conformational Changes in Pyruvate Formate-Lyase During the Catalysis
Autori
Čondić-Jurkić, Karmen ; Smith, Ana-Sunčana ; Smith, David M.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
Summer School "Fundamental Problems in Statistical Physics"
Mjesto i datum
Leuven, Belgija, 16.06.2013. - 29.06.2013
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
pyruvate formate lyase; catalysis; molecular dynamics; free energy
Sažetak
Pyruvate formate lyase is a radical enzyme that catalyzes a two-substrate reaction involving pyruvate and CoA. In this computational study, it was investigated is it possible that the chemical reaction with pyruvate in the active site serves as a trigger for the required conformational changes of PFL to allow approach of the second substrate, CoA, to the reaction center.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
098-0982933-2937 - Računalno proučavanje strukture i funkcije proteina (Smith, David Matthew, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
