Naslov
Novosti u patogenezi i liječenju membranskog glomerulonefritisa
(Membranous glomerulonephritis--recent advances in pathogenesis and treatment)

Autori
Horvatić I ; Galešić K

Izvornik
Liječnički vjesnik (0024-3477) 134 (2012); 328-339

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
membranski glomerulonefritis; patogeneza; liječenje
(membranous gloemrulonephritis; patogenesis; treatment)

Sažetak
Pathogenesis and treatment of the disease in recent years. In recent years, first human podocyte autoantigens, responsible for autoantibodies and in situ immune complexes formation, were discovered: neutral endopeptidase, m-type phospholipase A2 receptor, superoxide-dismutase 2, aldose-reductase, alpha-enolase. It is postulated that these discoveries will help in differentiation between primary and secondary membranous glomerulonephritis, in predicting remission and/or relapse and also in determining more specific therapy. There have been also some pilot studies recently, in which new drugs have been introduced in the treatment of membranous glomerulonephritis: ACTH, rituximab and tacrolimus.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA