Naslov
Ekspresija bcl-2, p53 i c-erB-2 kod gastritisa uzrokovanog Helicobacter pylori infekcijom
(Expression of bcl-2, p53, and c-erB-2 in Helicobacter pylori gastritis)

Autori
Dominis, Mara ; Brajša, Karmen ; Džebro, Sonja ; Ferenčić, Željko ; Katičić, Miroslava

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Drugi kongres Hrvatskog gastroenterološkog društva = 2nd Congress of the Croatian Society of Gastroenterology / Vucelić, Boris - Zagreb : Medicinska naklada, 1997, 191-191

Skup
Drugi kongres Hrvatskog gastroenterološkog društva s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 01.10.1997. - 03.10.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Helicobacter pylori; onkogeni produkti; gastritis; MALT limfom; želučani karcinom
(Helicobacter pylori; oncogene products; gastritis; MALT lymproma; gastric cancer)

Sažetak
There is an increasing evidence that Helicobacter pylori infection plays a major role in aetiology of gastric MALT lymphomas, and is also associated with conditions that could favour the development of gastric cancer (cell turnover, chronic immune response, increased levels of reactive oxygen, etc.) Aim: A large prospective study is designed to evaluate the importance of c-erB-2, bcl-2 and p53 oncogene products in relation to histological features in Helicobacter pylori gastritis, and their coexpression as a prognostic factor before and after eradication of Helicobacter pylori. Here we present preliminary data for ten patients. Methods: Biopsy samples were taken from corpus (2) and antrum (2) according to Sydney scheme and evaluated before and after standard triple therapy (omeprazole, amoxicyllin, metronidazol). The detection of c-erB-2, bcl-2 and p53 proteins was performed with standard immunohistochemical method using a streptavidine-biotin complex/HRP detection system (DAKO, Glostrup, Denmark) Results: Chronic active gastritis was found in three patients and chronic diffuse gastritis in seven. In three patients out of those seven after eradication of Hp histology of antral mucosa showed persistent diffuse chronic inflammation with formation of lymphatic follicules, dysplastic epithelial changes and intestinalisation. We found that p53 oncoprotein expression was related with poorer histological picture before therapy i.e. diffuse chronic gastritis, and coexpression with bcl-2 in well formed MALT resulted in worsening of the endoscopic as well as histological findings even after Helicobacter pylori eradication. Conclusion: This preliminary data indicate that coexpression and not only a single expression of studied oncoproteins, should be regarded as helpful prognostic marker in Helicobacter pylori gastritis evaluation.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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