Naslov
Uloga Helicobacter pylori infekcije i uzimanja nesteroidnih protuupalnih lijekova pri krvarenju iz gornjeg probavnog sustava
(Causative role of Helicobacter pylori and NSAIDs in upper gastrointestinal bleeding)

Autori
Tićak, Mirjana ; Katičić, Miroslava ; Presečki, Vladimir ; Prskalo, Marija ; Šabarić, Branka ; Kalenić, Smilja ; Dominis, Mara ; Džebro, Sonja ; Marušić, Marinko ; Papa, Branko ; Čolić-Cvrlje, Vesna ; Plečko, Vanda ; Naumovski-Mihalić, Slavica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Drugi kongres Hrvatskog gastroenterološkog društva = 2nd Congress of the Croatian Society of Gastroenterology / Vucelić, Boris - Zagreb : Medicinska naklada, 1997, 190-190

Skup
Drugi kongres Hrvatskog gastroenterološkog društva s međunarodnim sudjelovanjem

Mjesto i datum
Zagreb, Hrvatska, 01.10.1997. - 03.10.1997

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Helicobacter pylori; nesteroidni protuupalni lijekovi; gastroinestinelno krvarenje
(Helicobacter pylori; NSAID; gastrointestinal bleeding)

Sažetak
Background: Helicobacter pylori (HP) and NSAIDs both cause gastritis, peptic ulcers and their complications. Aim: The study was designed to evaluate the pathogenetic importance of HP infection and NSAIDs abuse in patients presenting with and without gastrointestinal bleeding. Methods: In an prospective study, 127 consecutive patients presenting with symptoms of an upper gastrointestinal bleeding (Group A) and 296 consecutive symptomatic patients without bleeding (Group B) were included. All patients were investigated clinically (a structured interview about drug history) and endoscopically. The HP status was assessed by means of urease test, culture, histology and serology. Statistical analysis was performed using Chi-square tests. Results: Variables Group A Group B ----------------------------------------------------------------------------------------------------------------- n = 127 n = 296 Age (mean ą SD) 56 ą 5.2 55 ą 6.1 NS Males 90 (71%) 162 (55%) p<0.01 H.pylori pozit. 104 (82%) 253 (85%) NS NSAIDs 50 (40%) 41 (14%) p<0.001 Gastric ulcers (HP poz -%) 31 (23-74%) 83 (76-90%) p<0.05 Duodenal ulcers (HP poz -%) 61 (55-90%) 140(135-96%) p<0.1 NSAIDs users (HP poz -%) 50 (41-82%) 41 (34-83%) NS Non NSAID users (HP poz.-%) 77 (63-82%) 255(219-86%) NS ------------------------------------------------------------------------------------------------------------------ Conclusions: The prevalence of men was higher in bleeding group. HP infection appears to be as frequent in bleeding as in non bleeding groups in general, bat more frequent in subgroups with gastric and duodenal non bleeding ulcers. NSAIDs abuse was significantly more frequent in bleeding group and probably play very important co-causal role in upper GI hemorrhage.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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