Pregled bibliografske jedinice broj: 66838
ROLE OF RECEPTOR TYROZINE -KINASE ACTIVITY IN INSULIN SIGNAL TRANSDUCTION
ROLE OF RECEPTOR TYROZINE -KINASE ACTIVITY IN INSULIN SIGNAL TRANSDUCTION // Conference on Signal Transduction, Abstracts / Đikić, i ; katić, M ; Pavelić, J ; Pavelić, K (ur.).
Zagreb, 1998. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 66838 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
ROLE OF RECEPTOR TYROZINE -KINASE ACTIVITY IN INSULIN SIGNAL TRANSDUCTION
(ROLE OF RECEPTOR TYROSINE-KINASE ACTIVITY IN INSULIN SIGNAL TRANSDUCTION)
Autori
Roša, Jagoda ; Roša, Josip
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Conference on Signal Transduction, Abstracts
/ Đikić, i ; katić, M ; Pavelić, J ; Pavelić, K - Zagreb, 1998
Skup
1st international Conference on signal Transduction
Mjesto i datum
Dubrovnik, Hrvatska, 08.10.1998. - 11.10.1998
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
hepatocytes; insulin; tyrosine-kinase
Sažetak
We studied the insulinomimetic effects of vanadium, a potent inhibitor of phosphotyrosine phosphatase on amino acid transport and on gluconeogenesis in cultured rat hepatocytes and implication of this pathway on insulin intracellular signalling to elucidate mechanisms of insulin action. In the presence of insulin and/or vanadate basal alfa-amino isobutiyric acid (AIB) uptake was increased by 100%. Basal and glucagon-stimulated gluconeogenesis was significantly decreased by insulin. Vanadate also decreased basal gluconeogenesis like insulin, but ther was no effect on glucagon-stimulated gluconeogenesis. Our data indicate that receptor tyrosine-kinaseactivity is associated withinsulin action on both AIB uptake and gluconeogenesis in hepatocytes. Morover, they suggest that a brancing of insulinsignal trnsduction occut at a post-receptor level.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
