Naslov
Antifungal effect of supersaturated calcium-phosphate oral rinse in xerostomia

Autori
Mravak-Stipetić, Marinka ; Jurčić Čulina, Ivana ; Belsey, Johnatan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Oral Diseases vol.18(suppl.1) / Scully, Crispian ; Baum, Bruce - Atena : Wiley-Blackwell, 2012, 20-20

Skup
11th Bienal Congress of the European Association of Oral Medicine

Mjesto i datum
Atena, Grčka, 13.09.2012. - 15.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
artificial saliva ; oral mucosa ; xerostomia ; oral yeast infection

Sažetak
Objectives: The aim was to investigate the effect of supersaturated calcium-phosphate oral rinse (Caphosol) on oral yeast infection in patients with dry mouth. Methods: In patients with xerostomia (N=120) (aged 67-89) unstimulated (QnS) and stimulated whole saliva (QsS) was measured and swabs were taken from oral mucosa for yeast culture . Patients with positive yeast culture were randomly assigned into four treatment groups (study group-A and control groups- B, C, D): Group A was treated with Caphosol, Group B with a combination of Caphosol and myconazole oral gel, Group C with a solution of sodium bicarbonate, and Group D with only myconazole oral gel. Treatment was carried out for 2 weeks. Control yeast culture and the amount of whole saliva (QnS and QsS) were determined in each subject at baseline, after 7 and 14 days. Between-group analysis was carried by using ANOVA. Results: All patients had positive yeast culture regardless of whether they had hyposalivation (87.50%) or normal salivation (12, 50%). The magnitude of change in salivary volume was greatest in caphosol group and significantly different compared to sodium bicarbonate (p<0.01). for period baseline-14 days. Significant decrease in fungal infection was shown for caphosol vs sodium bicarbonate (p<0.01), combination Caphosol-myconazole oral gel vs sodium bicarbonate (p<0.001) and myconazole vs sodium bicarbonate (p<0.01) in periods baseline-7days and baseline-14 days. No significant differences were found between groups Caphosol, Caphosol-myconazole and myconazole. Conclusion: Supersaturated calcium-phosphate oral rinse (Caphosol) increases amount of saliva and significantly reduces oral fungal infection, in comparison to sodium bicarbonate. Compared with myconazole alone and in combination with, no significant differences were found. Relevance: Antifungal effect of Caphosol, makes it a promising alternative for the local treatment of oral candidiasis in patients with xerostomia, particular when use of imidazoles is contraindicated.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Dentalna medicina

POVEZANOST RADA