Pregled bibliografske jedinice broj: 667202
The molecular links between lysosomal storage diseases and Alzheimer’s disease
The molecular links between lysosomal storage diseases and Alzheimer’s disease // Workshop New Developments of Lysosomal storage disease diagnostics & therapeutics: LSD Protein – aggregation & interactions
Konstanz, Njemačka, 2012. (pozvano predavanje, nije recenziran, neobjavljeni rad, znanstveni)
CROSBI ID: 667202 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
The molecular links between lysosomal storage diseases and Alzheimer’s disease
Autori
Katušić Hećimović, Silva
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Skup
Workshop New Developments of Lysosomal storage disease diagnostics & therapeutics: LSD Protein – aggregation & interactions
Mjesto i datum
Konstanz, Njemačka, 14.03.2012. - 16.03.2012
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Nije recenziran
Ključne riječi
Alzheimer's disease; amyloid-beta; APP; Cholesterol; Lysosomal storage; Niemann-Pick type C disease; NPC1
Sažetak
We analyzed the molecular links between Alzheimer's disease (AD) and Niemann-Pick type C disease (NPC) and showed that cholesterol indirectly modulates processing of the APP protein by regulating its trafficking within endocytic pathway leading to enhanced amyloidogenic APP cleavage by beta-secretase (BACE1).
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
098-0982522-2525 - Mehanizam djelovanja kolesterola u nastanku Alzheimerove bolesti (Katušić Hećimović, Silva, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Silva Katušić Hećimović
(autor)
