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Pregled bibliografske jedinice broj: 666078

Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex

Kwan, Kenneth Y.; Lam, Mandy M.S.; Johnson, Matthew B.; Dube, Umber; Shim, Sungbo; Rašin, Mladen-Roko; Sousa, André M.M.; Fertuzinhos, Sofia; Chen, Jie-Guang; Arellano, Jon I. et al.
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex // Cell, 149 (2012), 4; 899-911 doi:10.1016/j.cell.2012.02.060 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 666078 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex

Autori
Kwan, Kenneth Y. ; Lam, Mandy M.S. ; Johnson, Matthew B. ; Dube, Umber ; Shim, Sungbo ; Rašin, Mladen-Roko ; Sousa, André M.M. ; Fertuzinhos, Sofia ; Chen, Jie-Guang ; Arellano, Jon I. ; Chan, Daniel W. ; Pletikos, Mihovil ; Vasung, Lana ; Rowitch, David H. ; Huang, Eric J. ; Schwartz, Michael L. ; Willemsen, Rob ; Oostra, Ben A. ; Rakić, Paško ; Heffer, Marija ; Kostović, Ivica ; Judaš, Miloš ; Šestan, Nenad

Izvornik
Cell (0092-8674) 149 (2012), 4; 899-911

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cerebral cortex ; development ; NOS1 ; FMRP

Sažetak
Fragile X syndrome (FXS), the leading monogenic cause of intellectual disability and autism, results from loss of function of the RNA-binding protein FMRP. Here, we show that FMRP regulates translation of neuronal nitric oxide synthase 1 (NOS1) in the developing human neocortex. Whereas NOS1 mRNA is widely expressed, NOS1 protein is transiently coexpressed with FMRP during early synaptogenesis in layer- and region-specific pyramidal neurons. These include midfetal layer 5 subcortically projecting neurons arranged into alternating columns in the prospective Broca's area and orofacial motor cortex. Human NOS1 translation is activated by FMRP via interactions with coding region binding motifs absent from mouse Nos1 mRNA, which is expressed in mouse pyramidal neurons, but not efficiently translated. Correspondingly, neocortical NOS1 protein levels are severely reduced in developing human FXS cases, but not FMRP-deficient mice. Thus, alterations in FMRP posttranscriptional regulation of NOS1 in developing neocortical circuits may contribute to cognitive dysfunction in FXS.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
108-1081870-1878 - Uloga prolaznih fetalnih neurona u razvojnim poremećajima moždane kore (Judaš, Miloš, MZOS ) ( CroRIS)
108-1081870-1876 - Razvitak kortikalnih putova u čovjeka (Kostović, Ivica, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Sveučilište u Osijeku - Odjel za biologiju

Profili:

Avatar Url Lana Vasung (autor)

Avatar Url Ivica Kostović (autor)

Avatar Url Marija Heffer (autor)

Avatar Url Mihovil Pletikos (autor)

Avatar Url Miloš Judaš (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Kwan, Kenneth Y.; Lam, Mandy M.S.; Johnson, Matthew B.; Dube, Umber; Shim, Sungbo; Rašin, Mladen-Roko; Sousa, André M.M.; Fertuzinhos, Sofia; Chen, Jie-Guang; Arellano, Jon I. et al.
Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex // Cell, 149 (2012), 4; 899-911 doi:10.1016/j.cell.2012.02.060 (međunarodna recenzija, članak, znanstveni)
Kwan, K., Lam, M., Johnson, M., Dube, U., Shim, S., Rašin, M., Sousa, A., Fertuzinhos, S., Chen, J. & Arellano, J. (2012) Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex. Cell, 149 (4), 899-911 doi:10.1016/j.cell.2012.02.060.
@article{article, author = {Kwan, Kenneth Y. and Lam, Mandy M.S. and Johnson, Matthew B. and Dube, Umber and Shim, Sungbo and Ra\v{s}in, Mladen-Roko and Sousa, Andr\'{e} M.M. and Fertuzinhos, Sofia and Chen, Jie-Guang and Arellano, Jon I. and Chan, Daniel W. and Pletikos, Mihovil and Vasung, Lana and Rowitch, David H. and Huang, Eric J. and Schwartz, Michael L. and Willemsen, Rob and Oostra, Ben A. and Raki\'{c}, Pa\v{s}ko and Heffer, Marija and Kostovi\'{c}, Ivica and Juda\v{s}, Milo\v{s} and \v{S}estan, Nenad}, year = {2012}, pages = {899-911}, DOI = {10.1016/j.cell.2012.02.060}, keywords = {cerebral cortex, development, NOS1, FMRP}, journal = {Cell}, doi = {10.1016/j.cell.2012.02.060}, volume = {149}, number = {4}, issn = {0092-8674}, title = {Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex}, keyword = {cerebral cortex, development, NOS1, FMRP} }
@article{article, author = {Kwan, Kenneth Y. and Lam, Mandy M.S. and Johnson, Matthew B. and Dube, Umber and Shim, Sungbo and Ra\v{s}in, Mladen-Roko and Sousa, Andr\'{e} M.M. and Fertuzinhos, Sofia and Chen, Jie-Guang and Arellano, Jon I. and Chan, Daniel W. and Pletikos, Mihovil and Vasung, Lana and Rowitch, David H. and Huang, Eric J. and Schwartz, Michael L. and Willemsen, Rob and Oostra, Ben A. and Raki\'{c}, Pa\v{s}ko and Heffer, Marija and Kostovi\'{c}, Ivica and Juda\v{s}, Milo\v{s} and \v{S}estan, Nenad}, year = {2012}, pages = {899-911}, DOI = {10.1016/j.cell.2012.02.060}, keywords = {cerebral cortex, development, NOS1, FMRP}, journal = {Cell}, doi = {10.1016/j.cell.2012.02.060}, volume = {149}, number = {4}, issn = {0092-8674}, title = {Species-dependent posttranscriptional regulation of NOS1 by FMRP in the developing cerebral cortex}, keyword = {cerebral cortex, development, NOS1, FMRP} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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