Naslov
The prognostic significance of lymphopenia in peripheral T-cell and natural killer/T-cell lymphomas : a study of 826 cases from the International Peripheral T-cell Lymphoma Project

Autori
Mitrović, Zdravko ; Perry, Anamarija M. ; Suzumiya, Junji ; Armitage, James O. ; Au, Wing Y. ; Coiffier, Bertrand ; Holte, Harald ; Jaffe, Elaine S. ; Monserrat, Emili ; Rajan, Sandeep K. ; Savage, Kerry J. ; Tobinai, Kensei ; Vose, Julie M. ; Weisenburger, Dennis D.

Izvornik
American journal of hematology (0361-8609) 87 (2012), 8; 790-794

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
lymphocyte count; lymphoma extranodal NK-T-cell; lymphoma T-cell peripheral; lymphopenia

Sažetak
Lymphopenia is a marker of inferior survival in patients with various malignancies. However, the prognostic significance of lymphopenia in peripheral T-cell lymphoma (PTCL) is unclear. We analyzed the prognostic significance of lymphopenia in 826 patients with different types of PTCL and natural killer/T-cell lymphoma (NKTCL) from the International Peripheral T-cell Lymphoma Project. Lymphopenia was defined as an absolute lymphocyte count of less than 1, 000 cells per microliter. The overall frequency of lymphopenia was 35.3%, ranging from 21.1% in ALK+ anaplastic large cell lymphoma (ALCL) to 47.5% in angioimmunoblastic T-cell lymphoma (AITL). Lymphopenia was independently associated with an inferior overall survival (OS) in patients with the lymphoma type of adult T-cell leukemia/lymphoma (ATLL), with a 2-year OS of 15% versus 40% for those without lymphopenia (P < 0.001). Lymphopenia was also an adverse predictor of survival in PTCL, not otherwise specified, but was associated with other unfavorable prognostic factors. A trend toward inferior survival for lymphopenic patients was also observed in AITL, ALK− ALCL and extranasal NKTCL lymphoma, whereas no difference in survival was found in nasal NKTCL, ALK+ ALCL, or enteropathy-associated T-cell lymphoma. In this study, lymphopenia was identified as a new adverse prognostic factor in the lymphoma type of ATLL

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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