Naslov
Variants of the IL-23R and STAT3 gene are not associated with Hashimoto’s thyroiditis

Autori
Glavaš-Obrovac, Ljubica ; Suver Stević, Mirjana ; Štefanić, Mario ; Tokić, Stana ; Mihaljević, Silvio ; Karner, Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
FEBS Journal. 2013 ; 280 (Suppl. 1): 459. / - : John Wiley & Sons, 2013, 459-459

Skup
38th FEBS Congress: Mechanisms in Biology

Mjesto i datum
Sankt Peterburg, Ruska Federacija, 06.07.2013. - 11.07.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
interleukin-23 ; stat3 ; polymorphism ; genetic ; association ; study ; Croatia ; Hashimoto's thyroiditis
(St. Petersburg ; Russia)

Sažetak
Interleukin-23 receptor (IL-23R) and signal transducer and activator of transcription 3 (STAT3) polymorphisms are common risk factors for a number of T helper (Th) 17-mediated autoimmune diseases. However, the importance of genetic variations in Th17 pathways to thyroid autoimmunity, and particularly Hashimoto’s thyroiditis (HT), is not fully understood. In this study, we genotyped three single nucleotide polymorphisms (SNPs) within the IL- 23R(rs11209026/p.Arg381Gln, rs7530511) and STAT3 (rs744166) genes in 217 Croatian patients with HT and 161 healthy controls using fluorescence resonance energy transfer technology and melting curve analysis of polymerase chain reaction products. None of the tested SNPs or IL-23R haplotypes were associated with HT susceptibility or disease severity. These results suggest that the studied IL-23R/STAT3 polymorphisms affecting Th17 signaling efficiency are not major determinants of HT risk in the Croatian population. Further work is necessary to determine if these loci contribute modestly or conditionally to the risk of HT.

Izvorni jezik
Engleski

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