Naslov
The influence of arecoline, physostigmine and lecithin on the passive avoidance aquisition in the nucleus basalis lesioned rats

Autori
Simonić, Ante ; Župan, Gordana ; Atanacković, Dimitrije

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of Communications of 9th Congress of the Yugoslav Pharmacological Society and 4th Congress of the Yugoslav Toxicological Society / / - Beograd : Savez društava fiziologa Jugoslavije, 1985, 45-45

Skup
9th Congress of the Yugoslav Pharmacological Society and 4th Congress of the Yugoslav Toxicological Society

Mjesto i datum
Beograd, Jugoslavija, 11.09.1985. - 14.09.1985

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
nucleus basalis; arecoline; physostigmine; lecithine; passive avoidance; rat

Sažetak
Approximately 70% cholinergic projections of the frontoparietal neocortex is derived from ACh neurons in substantia innominata/nucl1eus basalis (SI/NB). The purpose of this study was to examine: 1) the influence of SI/NB lesion on the passive avoidance acquisition in the rat, and 2) if arecoline (1 mg/kg i.p.), physostigmine (0, 1 mg/kg i.p.) and lecithine (250 mg i.p.) may reverse the memory deficit of lesioned rats. Bilateral SI/NB lesion significantly impaired the passive avoidance acquisition related to the control group and sham lesioned rats. Acquisition was significantly improved in arecoline-treated rats, while physostigmine or lecithine didn't influence it significantly.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA