Naslov
Effects of piracetam, dihydroergotoxine and arecoline on the passive avoidance acquisition in the nucleus basalis lesioned rats

Autori
Simonić, Ante ; Župan, Gordana ; Atanacković, Dimitrije ; Krstulja, Mira

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the XIII Congress of the Union of Yugoslav Physiological Societies with International Participation / - Skopje, 1985, 102-102

Skup
XIII Congress of the Union of Yugoslav Physiological Societies with International Participation

Mjesto i datum
Skopje, Jugoslavija, 18.09.1985. - 21.09.1985

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
NBM lesion; passive avoidance; piracetam; dihydroergotoxine; arecoline

Sažetak
A major cholinergic projection to the neocortex originates from the cell bodies in the nucleus basalis of Maynert (NBM). Because the cholinergic system has a specific relationship to cognitive functions and lesions of NBM reduce memory, it was of interest to study the effect of piracetam (2 g/kg i.p.), dihydroergotoxine (DHE- 0.1 mg/kg i.p.) and arecoline (1.0 mg/kg i.p.) on the passive avoidance acquisition in the rat with NBM lesion. Bilateral NBM electrolytic lesion significantly impaired the passive avoidance acquisition related to the control group and sham lesioned rats. The avoidance acquisition deficit was improved by arecoline while piracetam or DHE didn't influence it statistically.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA