Naslov
Direct versus indirect cholinergic stimulation and passive avoidance aquisition in nucleus basalis lesioned rats

Autori
Simonić, Ante ; Župan, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of Ninth Congress of the Polish Pharmacological Society / - Lublin, 1986

Skup
Ninth Congress of the Polish Pharmacological Society

Mjesto i datum
Lublin, Poljska, 04.09.1986. - 05.09.1986

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Alzheimer; NBM lesions; passive avoidance; arecoline; THA; galantamine; physostigmine; rat

Sažetak
Alzheimer's disease is characterized clinically by cognitive deficits and histologically by a selective degeneration of neurons originating in the nucleus basalis of Maynert (NBM). The purpose of this study was to explore: 1. the influence of bilateral electrolytic lesions of NBM equivalent in rats on acquisition, and 2. if arecoline, THA, galantamine and physostigmine may influence acquisition in lesioned rats. NBM lesions significantly impaired the passive avoidance acquisition related to the control group. Acquisition was significantly improved in arecoline-treated rats, while AChE inhibitors didn't influence it significantly in experimental conditions used.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA