Naslov
The effects of nicardipine and nitrendipine on hypoxia induced memory impairment in the rat

Autori
Župan, Gordana ; Simonić, Ante ; Mršić, Jasenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Neuropsychopharmacology Vol.1, No.3, Abstracts of IVth Congress of European College of Neuropsychopharmacology / - Monte Carlo, 1991, 407-407

Skup
IVth Congress of European College of Neuropsychopharmacology

Mjesto i datum
Monte Carlo, Monako, 06.10.1991. - 09.10.1991

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
nicardipine; nitrendipine; hypoxia; passive avoidance; rat

Sažetak
Hypoxic damage of cell is associated with a precipitous influx of calcium from the extracellular to the intracellular compartment, and as a consequence, intracellular calcium concentration is increasing. The elevated cytosolic calcium concentration induces different vascular and biochemical disturbances like reduction in cerebral blood flow, impairment of the mitochondrial function with concomitant energy failure etc. Calcium entry blockers appear to inhibit calcium entry into cells by so-called slow channels and prevent metabolic disturbances and calcium homeostasis failure. The purpose of this study was to examine the effects of nicardipine and nitrendipine on learning ability in hypoxia exposed rats. The study was carried out on Hannover Wistar rats weighing 250 g. Various doses (0.03 ; 0.1 ; 0.3 ; 1.0 mg/kg) of nicardipine and nitrendipine were given intraperitoneally. Thirty minutes later passive avoidance task was performed according to the step-through procedure, modified by Jarvik and Kopp (1967). Immediately after the training animals were subjected to period of oxygen deprivation hypoxia. Rats were placed into hypoxia cage and the percentage of oxygen was gradually reduced and continuously measured. The level of 3.5 V% of oxygen was reached in about twenty minutes and maintained up to the loss of righting reflex. Twenty four hours later passive avoidance retention was tested by using mentioned step-through procedure. It has been found that both nicardipine and nitrendipine were effective in reversing the memory deficits in hypoxia exposed rats. All tested doses of nitrendipine and 0.3 or 1.0 mg/kg of nicardipine led to a significant enhancement of the passive avoidance in hypoxia treated rats. Nicardipine at the doses of 0.03 or 0.1 mg/kg slightly, but not significantly improved the performance of behavioral task. In conclusion, our results demonstrate that tested calcium entry blockers exerted protective effects against hypoxia induced memory disturbances.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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