Naslov
Effect of calcium channel blockers nitrendipine and felodipine on electroshock-induced amnesia in the rat

Autori
Župan, Gordana ; Matešić, Damir ; Simonić, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 347, Suppl., Abstracts of the 34th Spring Meeting / - Mainz, 1993, 137-137

Skup
34th Spring Meeting

Mjesto i datum
Mainz, Njemačka, 16.03.1993. - 18.03.1993

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
electroshock; amnesia; passive avoidance; nitrendipine; felodipine; rat

Sažetak
Electroshock-induced amnesia has been proposed as a technique for producing retrograde amnesia. The aim of our study was to investigate whether calcium channel blockers, nitrendipine and felodipine, can prevent memory disruption caused by electroshock (ECS) application. The study was carried out on Hannover Wistar rats weighing 150- 200 g. Various doses of nitrendipine or felodipine (0.03 ; 0.1 ; 0.3 ; 1.0 mg/kg) were given i.p. Thirty minutes later the passive avoidance task was performed according to the step-through procedure. A two-compartment apparatus with a grid floor which could be electrified was used. During the learning trial the rat was placed in the light compartment. After 30 seconds the guillotine door was opened and the latency between the door opening and the entrance into the dark compartment was measured. When the rat walked into the dark part of the apparatus it received a foot shock. Immediately after the training trial the animal received an ECS through the ears. The retention trial was carried out 24 hours later. It has been found that both tested drugs were effective in reversing the memory deficits in ECS- treated rats. Statistically significant enhancement of the passive avoidance behavior was produced by 0.1 ; 0.3 and 1. 0 mg/kg of nitrendipine and 1.0 mg/kg of felodipine.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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