Naslov
Effects of nimodipine and MK-801 on behavior in hypoxia-exposed rats

Autori
Župan, Gordana ; Mršić, Jasenka ; Simonić, Ante

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book of the First European Congress of Pharmacology / - , 1995, 265-265

Skup
First European Congress of Pharmacology

Mjesto i datum
Milano, Italija, 16.06.1995. - 19.06.1995

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cerebral hypoxia; passive avoidance; nimodipine; MK-801; rat

Sažetak
Cerebral hypoxia accompanies various clinical situations that are manifested with impairment of cognitive processes, especially memory functions. We hypothetized that disturbance in Ca2+ homeostasis might contribute to the memory deficits associated with cerebral hypoxia and that the pharmacological inhibition of the Ca2+ entry into the cells could antagonize cognitive deficits. Therefore in this study we examined the influence of nimodipine and MK-801 on the retention of passive avoidance in rats exposed to hypoxia. The study was carried out on Hannover- Wistar rats weighing 250 g. Various doses (0, 03 ; 0, 1 ; 0, 3 mg/kg) of nimodipine or MK-801 were administered intraperitoneally. Thirty minutes later the passive avoidance task was performed according to the step-through procedure. Immediately after the training trial the animals were subjected to the period of oxygen deprivation hypoxia. Twenty four hours later passive avoidance retention was tested. It was found that hypoxia strongly impaired the retention of the passive avoidance response. Nimodipine significantly improved the retention deficits in hypoxia-exposed rats while MK-801 was ineffective.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA