Naslov
Diversity of HLA-B*35 alleles and haplotypes among Croatians

Autori
Ćalušić, Marija ; Grubić, Zorana ; Štingl, Katarina ; Burek Kamenarić, Marija ; Žunec, Renata

Izvornik
Immunological investigations (0882-0139) 41 (2012), 8; 856-863

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
HLA-B*35; Croatian population; haplotypes

Sažetak
Objectives: Investigation of HLA-B*35 subtypes and haplotypes among Croatians. Methods: 4000 randomly selected unrelated donors from Croatian Bone Marrow Donor Registry were typed for HLA-A, -B and -DRB1 by PCR-LabType®SSO method. Results: Four different B*35 alleles (*35:01, *35:02, *35:03, *35:08) were found. Three of them were with similar frequencies as in other European Caucasians, while HLA-B*35:03 was two times more frequent in our population. Predicted haplotypes were also in accordance with present data from other populations. Conclusions: This study should be of benefit in the unrelated haematopoietic stem cell transplantation (HSCT) program. It should facilitate the recipient-donor matching and the selection of a suitable population for further searches.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA