Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells

Topić, Iva; Ikić, Marina; Ivčević, Sanja; Kovačič, Nataša; Marušić, Ana; Kušec, Rajko; Grčević, Danka

doi:10.1016/j.leukres.2013.03.002

Pregled bibliografske jedinice broj: 660473

Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells

Topić, Iva; Ikić, Marina; Ivčević, Sanja; Kovačič, Nataša; Marušić, Ana; Kušec, Rajko; Grčević, Danka

Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells // Leukemia research, 37 (2013), 6; 705-712 doi:10.1016/j.leukres.2013.03.002 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 660473 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells

Autori
Topić, Iva ; Ikić, Marina ; Ivčević, Sanja ; Kovačič, Nataša ; Marušić, Ana ; Kušec, Rajko ; Grčević, Danka

Izvornik
Leukemia research (0145-2126) 37 (2013), 6; 705-712

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Acute promyelocytic leukemia; Bone morphogenetic proteins; All-trans retinoic acid; Differentiation; ID genes; Cell lines; Patients

Sažetak
We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA. BMP and ATRA synergized in the induction of ID genes, causing suppression of differentiation. In primary acute promyelocytic leukemia bone-marrow samples, positive correlation of PML/RARα and negative of RARα with the expression of BMP-4, BMP-6 and ID genes were found. We concluded that BMPs may have oncogenic properties and mediate ATRA resistance by a mechanism that involves ID genes.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
108-1080229-0142 - Molekularni mehanizmi učinaka imunosnih poremećaja na kost (Grčević, Danka, MZOS ) ( CroRIS)
108-1080229-0341 - B limfociti, makrofagi i podrijetlo osteoklasta (Katavić, Vedran, MZOS ) ( CroRIS)
108-1080229-0140 - Molekularne interakcije koštanog i imunološkog sustava (Marušić, Ana, MZOS ) ( CroRIS)
108-1980955-3094 - Genetika i funkcija hematopoeze i mikrookoliša Ph- mijeloproliferativnih bolesti (Kušec, Rajko, MZOS ) ( CroRIS)