Naslov
Sequence Analysis of Membrane Proteins: The Twilight Zone.

Autori
Juretić, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
MATH/CHEM/COMP '98 / Živković, Tomislav ; Vikić-Topić Dražen - Zagreb, 1998

Skup
The Thirteenth Dubrovnik International Course&Conference on the Interfaces among Mathematics, Chemistry and Computer Sciences

Mjesto i datum
Dubrovnik, Hrvatska, 22.06.1998. - 27.06.1998

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
sequence analysis; membrane proteins; interface segments

Sažetak
One goal of sequence analysis is to predict the emergence of secondary structure such as alpha-helices, beta-sheets and turns in a chosen polypeptide. The best algorithms for soluble proteins predict about 73% of amino acid residues with correct secondary conformation, while the best algorithms for membrane proteins predict about 95% of transmembrane helices with correct sequence location. However, it is difficult to predict sequence location and conformation of residues at the phase boundary between lipid and water phase: at the twilight zone. What can recently solved crystal structures of membrane proteins tell us about performance of structure prediction for the phase boundary domain? Are there secondary structure elements that are neither transmembrane nor extramembrane? Are any of such segments associated with the ion passage and/or signal transduction between phases? Can one predict sequence location and conformation of phase-boundary segments that perform their signal or energy transducting function through conformational change? These are the questions that will be discussed in the lecture.

Izvorni jezik
Engleski

Znanstvena područja
Fizika

POVEZANOST RADA