Naslov
Topological signals in integral membrane proteins

Autori
Juretić, Davor

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of abstracts of the papers of the seventh congress of Croatian biologists / Ljubešić, Nikola, ml. - Zagreb : Hrvatsko biološko društvo, 2000, 36-37

Skup
7. Hrvatski biološki kongres

Mjesto i datum
Hvar, Hrvatska, 24.09.2000. - 29.09.2000

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
topological signals; membrane proteins

Sažetak
The frequency of membrane proteins in genomes of different organisms is 20-30%. Integral membrane proteins pass one or more times through phospholipid membrane, so that simple two-dimensional models of their transmembrane structure can be created. The topological model is complete when protein orientation is known as well. It is the information about cytoplasmatic or extracytoplasmatic location of protein N-terminus that defines its transmembrane helices. Their sequence locations can be determined by using hydrophobicity analysis of the protein sequences. Protein transmembrane orientation can also be predicted from its sequence if topological signals are found in the sequence. We show what are the most useful and the most accurate topological signals for predicting membrane protein N-terminus location.

Izvorni jezik
Engleski

Znanstvena područja
Fizika

POVEZANOST RADA