Naslov
Cardiac biomarkers predict outcome after hospitalization for an acute exacerbation of chronic obstructive pulmonary disease

Autori
Marčun, Robert ; Šustić, Alan ; Brguljan, Pika Meško ; Kadivec, Saša ; Farkaš, Jerneja ; Košnik, Mitja ; Stewart Coast, Andrew Justin ; Anker, Stefan D ; Lainšćak, Mitja

Izvornik
International journal of cardiology (0167-5273) 161 (2012), 3; 156-159

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
biomarkers; chronic obstructive pulmonary disease; outcome

Sažetak
In chronic obstructive pulmonary disease (COPD), cardiovascular system is involved but less is known about role of specific cardiac biomarkers. We aimed to investigate associations between N- terminal pro B-type natriuretic peptide (NT- proBNP) and troponin T during hospitalisation with 6-month outcome. This was a prospective study conducted in consecutive patients hospitalized for an acute exacerbation of COPD. On admission, and at discharge, NT-proBNP and troponin T were measured, and echocardiography was performed. Hospitalisations and mortality were recorded for 6 months after discharge. RESULTS: We included 127 patients (70 ± 10 years, 70% men, GOLD III/IV 87%). Left ventricular dysfunction was detected in 70 (55%) patients and diastolic dysfunction was the most common type (53 patients- 42%). NT-proBNP and troponin T were elevated on admission in 60% and 36%, and at discharge in 28% and 19% of patients. During follow-up, 53 (42%) patients were hospitalized and 17 (13%) patients died. In Kaplan Meier analysis of survival curves, NT-proBNP on admission distinguished between deceased and surviving patients (p=0.011) whilst troponin T at discharge separated hospitalized and non-hospitalized patients (p=0.017). The adjusted Cox proportional hazard model confirmed these findings: discharge troponin T predicted hospitalisations (hazard ratio 2.89, 95% confidence interval 1.13-7.36) and admission NT- proBNP predicted mortality (hazard ratio 4.20, 95% confidence interval 1.07-14.01). Elevated NT-proBNP at discharge and troponin T on admission predict outcome in patients hospitalized for an acute exacerbation of COPD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA