Naslov
Imunoreakcije u hemoragijskoj vrućici s bubrežnim sindromom uzrokovanoj virusom Puumala
(Immunoreactions in hemorrhagic fever with renal syndrome caused by Puumala virus)

Autori
Cvetko Krajinović, Lidija ; Paessler, Slobodan ; Tadin, Ante ; Svoboda, Petra ; Kurolt, Ivan-Christian ; Topić, Antea ; Čivljak, Rok ; Kuzman, Ilija ; Markotić, Alemka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
CROCMID 2013 Knjiga sažetaka/Abstract book / Bradarić, Nikola ; Tambić Andrašević Arjana - Zagreb : Hrvatski liječnički zbor / Croatian Medical Association Hrvatsko društvo za kliničku mikrobiologiju / Croatian Society of Clinical Microbiology Hrvatsko društvo za infektivne bolesti / Croatian Society of Infectious Diseases, 2013, 85-85

Skup
10. hrvatski kongres kliničke mikrobiologije i 7. hrvatski kongres o infektivnim bolestima

Mjesto i datum
Rovinj, Hrvatska, 24.10.2013. - 27.10.2013

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
HFRS; miRNA; PBMC; PUUV

Sažetak
Pathogenic hantaviruses in Europe cause hemorrhagic fever with renal syndrome (HFRS). HFRS is considered an immune-mediated disease with strong proinflammatory response. Hantaviruses markedly differ in the level of their pathogenicity ranging in a broad spectrum of HFRS clinical conditions. Factors influencing such differences and appropriate immune response which hantaviruses induce in humans are still poorly explored. We searched here for the main elements of the innate and adaptive immune responses in HFRS patients infected with Puumala virus (PUUV). PUUV infection generated down-regulation of anti-viral responsive gene expression in peripheral blood mononuclear cells (PBMC) in early phase of disease. Furthermore, over-expression as well as over-production of certain cytokines and chemokines has been observed. To further asses the mechanisms of Puumala virus-induced modulation of host peripheral immune response, we examined host cellular microRNA (miRNA) expression profiles of peripheral circulation in PUUV infected patients. Several miRNAs were up-regulated upon the infection. Moreover, the observed differences were also associated with the disease severity. This study suggests that disregulation of host immune response genes by the cellular miRNAs may be involved in the pathogenesis of PUUV infection.

Izvorni jezik
Hrvatski, engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA