Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 654082

The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression

Skelin, Ivan; Kovačević, Tomislav; Sato, Hiroki; Dikšić, Mirko
The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression // Brain research bulletin, 88 (2012), 5; 477-486 doi:10.1016/j.brainresbull.2012.04.009 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 654082 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression

Autori
Skelin, Ivan ; Kovačević, Tomislav ; Sato, Hiroki ; Dikšić, Mirko

Izvornik
Brain research bulletin (0361-9230) 88 (2012), 5; 477-486

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Flinders Sensitive Line; Flinders Resistant Line; depression; 5-HT1B receptor; α-MTrp; autoradiography; serotonin synthesis rate

Sažetak
Flinders Sensitive Line (FSL) rat is as an animal model of depression with altered parameters of the serotonergic (5-HT) system function (5-HT synthesis rates, tissue concentrations, release, receptor density and affinity), as well as an altered sensitivity of these parameters to different 5-HT based antidepressants. The effects of acute and chronic treatments with the 5-HT1B agonist, CP-94253 on 5-HT synthesis, in the FSL rats and the Flinders Resistant Line (FRL) controls were measured using α-[14C]methyl-l-tryptophan (α-MTrp) autoradiography. CP-94253 (5 mg/kg), or an adequate volume of saline, was injected i.p. as a single dose in the acute experiment or delivered via the subcutaneously implanted osmotic minipump (5 mg/kg/day for 14 days) in the chronic experiment. The acute treatment with CP-94253 significantly decreased the 5-HT synthesis in both the FRL and FSL rats, with a more widespread effect in the FRL rats. Chronic treatment with CP-94253 significantly decreased 5-HT synthesis in the FRL rats, while 5-HT synthesis in the FSL rats was significantly increased throughout the brain. In both the acute and chronic experiment, the FRL rats had higher brain 5-HT synthesis rates, relative to the FSL rats. The shift in the direction of the treatment effect from acute to chronic, using the 5-HT1B agonist, CP-94253, on 5-HT synthesis in the FSL model of depression, with an opposite effect on the control FRL rats, suggests the differential adaptation of the 5-HT system in the FSL and FRL rats to chronic stimulation of 5-HT1B receptors.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
219-1081870-2032 - Serotoninski receptori te promjena antidepresivima u štakorskom modelu depresije (Dikšić, Mirko, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Mirko Dikšić (autor)

Avatar Url Tomislav Kovačević (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Skelin, Ivan; Kovačević, Tomislav; Sato, Hiroki; Dikšić, Mirko
The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression // Brain research bulletin, 88 (2012), 5; 477-486 doi:10.1016/j.brainresbull.2012.04.009 (međunarodna recenzija, članak, znanstveni)
Skelin, I., Kovačević, T., Sato, H. & Dikšić, M. (2012) The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression. Brain research bulletin, 88 (5), 477-486 doi:10.1016/j.brainresbull.2012.04.009.
@article{article, author = {Skelin, Ivan and Kova\v{c}evi\'{c}, Tomislav and Sato, Hiroki and Dik\v{s}i\'{c}, Mirko}, year = {2012}, pages = {477-486}, DOI = {10.1016/j.brainresbull.2012.04.009}, keywords = {Flinders Sensitive Line, Flinders Resistant Line, depression, 5-HT1B receptor, α-MTrp, autoradiography, serotonin synthesis rate}, journal = {Brain research bulletin}, doi = {10.1016/j.brainresbull.2012.04.009}, volume = {88}, number = {5}, issn = {0361-9230}, title = {The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression}, keyword = {Flinders Sensitive Line, Flinders Resistant Line, depression, 5-HT1B receptor, α-MTrp, autoradiography, serotonin synthesis rate} }
@article{article, author = {Skelin, Ivan and Kova\v{c}evi\'{c}, Tomislav and Sato, Hiroki and Dik\v{s}i\'{c}, Mirko}, year = {2012}, pages = {477-486}, DOI = {10.1016/j.brainresbull.2012.04.009}, keywords = {Flinders Sensitive Line, Flinders Resistant Line, depression, 5-HT1B receptor, α-MTrp, autoradiography, serotonin synthesis rate}, journal = {Brain research bulletin}, doi = {10.1016/j.brainresbull.2012.04.009}, volume = {88}, number = {5}, issn = {0361-9230}, title = {The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression}, keyword = {Flinders Sensitive Line, Flinders Resistant Line, depression, 5-HT1B receptor, α-MTrp, autoradiography, serotonin synthesis rate} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.