Naslov
Magnesium – more than a common cation
(Magnezij – više od običnog kationa)

Autori
Čepelak, Ivana ; Dodig, Slavica ; Čulić, Ognjen

Izvornik
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti (1330-5301) 39 (2013); 47-68

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, ostalo

Ključne riječi
magnezij; hipomagnezijemija; hipermagnezijemija; terapijske aplikacije magnezija
(magnesium; hypomgnesemia; hypermagnesemia; therapeutic applications)

Sažetak
Magnesium is an essential biological cation, participating in whole spectrum of biological functions. It is an irreplaceable factor for more than 300 enzymatic reactions, including those that use ATP as chemical energy source. Only about 1% of whole body magnesium is present in plasma. Normal plasma concentrations are in a range: 0.75-1.00 mmol/L. Concentrations lower or higher than in this interval are called hypomagnesemia and hypermagnesemia, respectively. Those are life treathening conditions. Hypomagnesemia requires quick i.v. supplementation with magnesium cation. In addition to hypoamgnesemia, we are nowadays aware of a common “invisible” deficit of magnesium in tissues. This is a result of changing nutrition habits causing an insufficient recommended daily uptake (>300mg daily). Large clinical studies have shown that magnesium status is negatively correlated with incidence and severity of diabetes type 2, metabolic syndrome, hypertension and some arrhythmias. Therefore, food supplementation with magnesium is one of positive therapeutic or prevention options. Future larger clinical studies are expected to provide information on usefulness of supplementation in some other common diseases and syndromes (e.g. migraine, fibromyalgia, coronary artery disease, chronic fatigue syndrome).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA