Naslov
Total antioxidant status in patients with acute pancreatitis

Autori
Vukelić, Nada ; Stanković, Helena ; Topić, Elizabeta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biochemia Medica, vol 10, 6th Alps-Adria congress of clinical chemistry and laboratory medicine-abstracts / Suchanek, Ernest - Zagreb : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM), 2000

Skup
6th Alps-Adria congress of clinical chemistry and laboratory medicine

Mjesto i datum
Orlando (FL), Sjedinjene Američke Države, 15.06.2000. - 17.06.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
TAS; acute pancreatitis

Sažetak
Acute pancreatitis is an autodigestive disease associated with activation of many enzymes in the pancreatic tissue and their entry in the circulation. The most common causes of acute pancreatitis include biliary tract disease and alcohol abuse. Recent studies have shown the bile, duodenal juice and pancreatic tissue of these patients to contain increased amounts of lipid peroxidation products. As lipid peroxidation occurs consequentially to the toxic action of free radicals on lipid molecules, these results point to the active role of free radicals in the genesis of acute pancreatitis. The body has a complex mechanism of defense, which protects the cells and biomolecules from the harmful effects of free radicals. The aim of the study was to assess the functional capacity of the overall antioxidative mechanism of defense in patients with acute pancreatitis. Study group included 41 patients of both sexes with clinical signs of the disease. Blood samples were obtained on a single occasion in the initial stage of the disease. The values of total antioxidative status (TAS) in plasma, and of alfa amylase and lipase in serum as standard markers of the disease, were determined. Control group consisted of 48 subjects of both sexes without clinical signs of the disease, in whom the same parameters were determined. The following results were obtained ( x ą SD ) : TAS ( mmol/L ) : patient group 1,23 ą 0,18 ; control group 1,51ą 0,13 alfa amylase ( U/L) : patient group 761 ą 621 ; control group 33 ą 19 lipase ( U/L ) : patient group 5133 ą 4077 ; control group 128 ą 51 Statistical analysis of the results yielded statistically significantly lower TAS values, and statistically significantly higher alfa amylase and lipase values in the group of patients with acute pancreatitis than in the control group ( p < 0,05 both ). The decreased values of TAS in the acute pancreatitis patients pointed to a reduced antioxidative capacity of the defense system as a whole, due to the increased production of free radicals which had surpassed the defense system capacity and led to its exhaustion.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA