Naslov
Microstructural alterations of femoral head articular cartilage and subchondral bone in osteoarthritis and osteoporosis

Autori
Bobinac, Dragica ; Ćelić, Tanja ; Marinović, Marin ; Marić, Ivana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Bone Abstracts / ECTS 2013 Scientific Programme Committee - Lisabon : BioScientifica, 2013, 138-138

Skup
ECTS 2013

Mjesto i datum
Lisabon, Portugal, 18.05.2013. - 21.05.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Cartilage alterations; Osteoarthritis; Osteoporosis; Subchondral cortical bone; Subchondral trabecular bone

Sažetak
The aim was to explore whether osteoporosis in humans influences the morphological status of the cartilage and subchondral bone, and relationship between macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone. Femoral heads were obtained from 68 patients with osteoporosis (OP) and hip OA (OP, n=56 ; OA, n=12) during surgery. Evaluation of the cartilage of degeneration was done by Mankin grading system while bone alterations were evaluated using micro-CT scanning system. Total Mankin score according the cartilage degeneration differed between all OP specimens. In OP with preserved cartilage, we observed increased thickness of subchondral cortical bone (SCB) due to increased bone remodeling whereas subchondral trabecular bone (SCB) parameters were slightly decreased. In OP with severe rate of cartilage damage we found thinning of SCB and significant decrease in BV/TV and trabecular parameters. In OA SCB and STB were thicker. Thinning of SCB in OP was related to the progression of cartilage degeneration what could implicate early-stage OA. Severe cartilage degeneration and intensive activates in SCB in OP and OA suggested that progression of cartilage damage was influenced by altered activities in SCB.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA