Naslov
Longterm effect of American ginseng extract (Panax quinquefolius l.) on glycemic control in type 2 diabetic patients.

Autori
Mucalo, Iva ; Rahelić, Dario ; Jovanovski, Elena ; Božikov, Velimir ; Romić, Željko ; Vuksan, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
5. hrvatski dijabetološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Pula, Hrvatska, 15.05.2013. - 19.05.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
glycemic control; diabetes; ginseng; american ginseng

Sažetak
The objective of the present study was to test the efficacy and safety of supplementation with the selected American ginseng extract (AG) as an adjunct to their usual anti-diabetic therapy (diet and/or medications), using a double-blind, randomized, placebo-controlled, parallel design. Each participant received either the selected AG preparation (ethanol extract) or placebo (500 mg/meal = 3 g/day) for a period of 12 weeks. Outcomes included measures of efficacy (glycated hemoglobin (HbA1c)-primary, fasting plasma glucose (FPG), fasting plasma insulin (FPI), and HOMA) ; safety (liver and kidney function) ; and compliance (returned capsules and body-weight). Seventy-four participants with well-controlled type 2 diabetes (sex: 28 M: 46 F, age: 62, 9±9, 49, BMI: 32±5, 3, HbA1c: 7±1, 3), randomized to either intervention (n= 35) or control (n=39) group, completed the study. There was no change in the primary endpoint, HbA1c. Nevertheless, there was a trend toward lower HbA1c by 0.84% (P=0.836) compared to placebo. Furthermore, the participants remained well-controlled (HbA1c = 7.12%) throughout. The selected AG treatment also decreased FPG, FPI and HOMA by 4.42, 11.54 and 18.84%, respectively, with no significant between-treatment difference (P=0.947, P=0.373, P=0.489, respectively). Safety and compliance outcomes remained unchanged. Although clinical efficacy, as assessed by HbA1c, was not demonstrated, 12 weeks of supplementation with the selected AG treatment maintained good glycemic control in people with well-controlled type 2 diabetes without adverse effects.

Izvorni jezik
Engleski

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