Naslov
Obesity - independent risk factor for cardiomyopathy?

Autori
Selthofer-Relatić , Kristina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Cardiologia Croatica / - , 2012

Skup
9. Kongres hrvatskog kardiološkog društva

Mjesto i datum
Zagreb, Hrvatska, 13.10.2012. - 16.10.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
cardiomyopathy; obesity

Sažetak
According to World Health Organisation obesity is global epidemic problem, with serious health complications and consequences like psyhosocial stress, physical morbidity, premature death. Obesity is chronic disorder and risk factor for conventional cardiometabolic risk factors, but is it independent risk factor for cardiac hypertrophy and cardiomyopathy? Adipose tissue acting as active endocrine organ with possibility of synthesis of many bioactive molecules, such as proinflammatory interleukins, cytokines, chemokines and adipokines. Concentrations of many adipokines are changing with the body mass index and body fat distribution, where visceral adipose tisue plays a more determinant role in defining related disease risk than subcutaneous adipose tissue. According to latest research, obesity is related to dyslipidemia, diabetes mellitus, hypertension, ishaemic heart disease, heart failure, chronic kidney disease and anxiodepresive disorders. Adipokines, product of adipose tissue, induce changes of related tissue and organs trought the process of inflammation, vasoconstriction, insulin resistance, oxidative stress, endothelial dysfunction and increased concentrations of free fatty acids. It can be concluded that obesity affect the cardiomyopathy development trough haemodynamic factors that cause left ventricular hypertrophy and trough non-hemodynamic, neurohumoral factors such as adipocytokine dysregulation and inflammation affecting cardiomyocytes and myocardium by depositing triglycerides and free fatty acids, myocardium matrix remodelling, trough activation of hypertrophic and profibrotic signals.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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