Naslov
Pathophysiological relevance of aldehydic protein modifications

Autori
Žarković, Neven ; Čipak, Ana ; Jaganjac, Morana ; Borović, Suzana ; Žarković, Kamelija

Izvornik
Journal of proteomics (1874-3919) 92 (2013); 239-247

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
4-Hydroxy-2-nonenal (HNE); Acrolein (ACR); Immunochemistry; Malondialdehyde (MDA); Non-enzymatic protein modifications; Oxidative stress

Sažetak
There is growing body of evidence that oxidative stress, i.e. excess in production of reactive oxygen species, can lead to covalent modification of proteins with bioactive aldehydes that are mostly produced under lipid peroxidation of polyunsaturated fatty acids. Thus generated reactive aldehydes are considered as second messengers of free radicals because they react with major bioactive macromolecules, in particular with various humoral and cellular proteins changing their structure and functions. Therefore, the aldehydic-protein adducts, in particular those involving 4-hydroxy-2-nonenal, malondialdehyde and acrolein can be valuable biomarkers of numerous pathophysiological processes. The development of immunochemical methods is increasing the possibilities to study such non-enzymatic protein modifications, on the one hand, while on the other hand the increase of knowledge on bioactivities of the aldehydes and their protein adducts might lead to better prevention, diagnosis and treatments of pathophysiological processes associated with lipid peroxidation and oxidative stress in general.

Izvorni jezik
Engleski

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