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Pregled bibliografske jedinice broj: 648428

Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription

Aliotta, Jason; Pereira, Mandy; Johnson, Kevin; de Paz, Nicole; Dooner, Mark; Puente, Napoleon; Ayalac, Carol; Brilliant, Kate; David Berz, David; Lee, David et al.
Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription // Experimental hematology, 38 (2010), 3; 233-245 doi:10.1016/j.exphem.2010.01.002 (međunarodna recenzija, članak, znanstveni)

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Naslov
Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription

Autori
Aliotta, Jason ; Pereira, Mandy ; Johnson, Kevin ; de Paz, Nicole ; Dooner, Mark ; Puente, Napoleon ; Ayalac, Carol ; Brilliant, Kate ; David Berz, David ; Lee, David ; Ramratnamd, Bharat ; McMillan, Paul ; Hixson, Douglas ; Josić, Djuro , Djuro ; Quesenberry, Peter Napoleon

Izvornik
Experimental hematology (0301-472X) 38 (2010), 3; 233-245

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
microvesicles; marrow cells; induction of transcription

Sažetak
Microvesicles have been shown to mediate intercellular communication. Previously, we have correlated entry of murine lung-derived microvesicles into murine bone marrow cells with expression of pulmonary epithelial cell- specific messenger RNA (mRNA) in these marrow cells. The present studies establish that entry of lung-derived microvesicles into marrow cells is a prerequisite for marrow expression of pulmonary epithelial cell-derived mRNA. Murine bone marrow cells cocultured with rat lung, but separated from them using a cell- impermeable membrane (0.4-mm pore size), were analyzed using species-specific primers (for rat or mouse). These studies revealed that surfactant B and C mRNA produced by murine marrow cells were of both rat and mouse origin. Similar results were obtained using murine lung cocultured with rat bone marrow cells or when bone marrow cells were analyzed for the presence of species-specific albumin mRNA after coculture with rat or murine liver. These studies show that microvesicles both deliver mRNA to marrow cells and mediate marrow cell transcription of tissue-specific mRNA. The latter likely underlies the longer-term stable change in genetic phenotype that has been observed. We have also observed microRNA in lung- drived microvesicles, and studies with RNase- treated microvesicles indicate that microRNA negatively modulates pulmonary epithelial cell- specific mRNA levels in cocultured marrow cells. In addition, we have also observed tissue-specific expression of brain, heart, and liver mRNA in cocultured marrow cells, suggesting that microvesicle-mediated cellular phenotype change is a universal phenomena. These studies suggest that cellular systems are more phenotypically labile than previously considered.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biotehnologija



POVEZANOST RADA

Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Đuro Josić (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Aliotta, Jason; Pereira, Mandy; Johnson, Kevin; de Paz, Nicole; Dooner, Mark; Puente, Napoleon; Ayalac, Carol; Brilliant, Kate; David Berz, David; Lee, David et al.
Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription // Experimental hematology, 38 (2010), 3; 233-245 doi:10.1016/j.exphem.2010.01.002 (međunarodna recenzija, članak, znanstveni)
Aliotta, J., Pereira, M., Johnson, K., de Paz, N., Dooner, M., Puente, N., Ayalac, C., Brilliant, K., David Berz, D. & Lee, D. (2010) Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription. Experimental hematology, 38 (3), 233-245 doi:10.1016/j.exphem.2010.01.002.
@article{article, author = {Aliotta, Jason and Pereira, Mandy and Johnson, Kevin and de Paz, Nicole and Dooner, Mark and Puente, Napoleon and Ayalac, Carol and Brilliant, Kate and David Berz, David and Lee, David and Ramratnamd, Bharat and McMillan, Paul and Hixson, Douglas and Quesenberry, Peter Napoleon}, year = {2010}, pages = {233-245}, DOI = {10.1016/j.exphem.2010.01.002}, keywords = {microvesicles, marrow cells, induction of transcription}, journal = {Experimental hematology}, doi = {10.1016/j.exphem.2010.01.002}, volume = {38}, number = {3}, issn = {0301-472X}, title = {Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription}, keyword = {microvesicles, marrow cells, induction of transcription} }
@article{article, author = {Aliotta, Jason and Pereira, Mandy and Johnson, Kevin and de Paz, Nicole and Dooner, Mark and Puente, Napoleon and Ayalac, Carol and Brilliant, Kate and David Berz, David and Lee, David and Ramratnamd, Bharat and McMillan, Paul and Hixson, Douglas and Quesenberry, Peter Napoleon}, year = {2010}, pages = {233-245}, DOI = {10.1016/j.exphem.2010.01.002}, keywords = {microvesicles, marrow cells, induction of transcription}, journal = {Experimental hematology}, doi = {10.1016/j.exphem.2010.01.002}, volume = {38}, number = {3}, issn = {0301-472X}, title = {Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription}, keyword = {microvesicles, marrow cells, induction of transcription} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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