Naslov
The Maillard reaction induced modifications of endogenous opioid peptide enkephalin

Autori
Jakas, Andreja

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Peptide modification to increase metabolic stability and activity

Urednik/ci
Cudic, Predrag

Izdavač
Springer

Grad
New York (NY)

Godina
2013

Raspon stranica
137-149

ISBN
978-1-62703-651-1

Ključne riječi
amadori compounds, endogenous opioid peptides, fructose, glucose, heyns compounds, leucine-enkephalin, Maillard reaction, methionine-enkephalin

Sažetak
Nonenzymatic glycation (Maillard reaction) is a posttranslational modification of peptides and proteins by sugars, which, after a cascade of reactions, leads to the formation of a complex family of irreversibly changed advanced glycation end products (AGE) implicated in the pathogenesis of human diseases. Last reversible intermediates of this reaction are Amadori/Heyns compounds formed in glucose/fructose induced modification of peptides. The stability of these compounds determines the further course of the reaction. To provide information concerning the preparation of model systems as well as the fate of glycated opioid peptides introduced in the human circulation, the enzymatic (80 % human serum) and chemical (PBS) stability of Amadori and Heyns compounds related to the endogenous opioid pentapeptides leucine- and methionine-enkephalin (Tyr-Gly-Gly-Phe-Leu/Met) were investigated.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA