Naslov
Opine dehydrogenases in marine invertebrates

Autori
Harcet, Matija ; Perina, Dragutin ; Pleše, Bruna

Izvornik
Biochemical genetics (0006-2928) 51 (2013), 9/10; 666-676

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
anaerobic pathways; opine dehydrogenases; marine invertebrates; Porifera
(anaerobic pathways; opine dehydrogenases; mMarine invertebrates; Porifera)

Sažetak
It is well known today that opine production anaerobic pathways are analogs to the classical glycolytic pathway (lactate production pathway). These pathways, catalyzed by a group of enzymes called opine dehydrogenases (OpDHs), ensure continuous flux of glycolysis and a constant supply of ATP by maintaining the NADH/NAD+ ratio during exercise and hypoxia, thus regulating the cytosolic redox balance in glycolysis under anoxia. OpDHs are distributed in a wide range of marine invertebrate phyla, including sponges (Porifera). Phylogenetic analyses supported with enzymatic assays strongly indicate that sponge OpDHs constitute an enzyme class unrelated to other OpDHs. Therefore, OpDHs in marine invertebrates are divided into two groups, a mollusk/annelid type and a sponge type, which belongs to the OCD/mu-crystallin family.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA