Naslov
Conformational Behaviour of 11-O-Methylazithromycin in the Solid and Solution State

Autori
Košutić-Hulita, Nada ; Matak-Vinković, Dijana ; Vinković, Mladen ; Novak, Predrag ; Kobrehel, Gabrijela ; Lazarevski, Gorjana

Izvornik
Croatica chemica acta (0011-1643) 74 (2001), 2; 327-341

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azithromycin; crystal structure; molecular replacement; NMR

Sažetak
Conformational behaviour of azithromycin 11-OMe derivative 2 (Scheme I) has been studied in the solid and solution state. In the CDCl3 and DMSO solution 2 adopts mainly "folded-in" conformation. 11-OMe group is oriented toward the centre of aglycone ring. The crystal structure of DMSO solvate of 2 has been solved by molecular replacement method using solution state conformation as search model. Conformation of 2 in the solid and solution state is very similar. Molecules of 2 are held together in the crystal by Van der Waals interactions forming a solvent chanel along the b axis. The DMSO molecule is found to be disordered and bound to cladinose moiety of 2 by H-bond O4"-H...O1s.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA