Pregled bibliografske jedinice broj: 646668
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties // Acta pharmaceutica, 63 (2013), 3; 409-418 doi:10.2478/acph-2013-0023 (međunarodna recenzija, kratko priopcenje, znanstveni)
CROSBI ID: 646668 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties
Autori
Perković, Ivana ; Rajić Džolić Zrinka ; Zorc, Branka
Izvornik
Acta pharmaceutica (1330-0075) 63
(2013), 3;
409-418
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kratko priopcenje, znanstveni
Ključne riječi
NSAID; ester; amino acid; benzotriazole; urea; amide
Sažetak
A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.
Izvorni jezik
Engleski
Znanstvena područja
Farmacija
POVEZANOST RADA
Projekti:
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Zorc, Branka, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
Uključenost u ostale bibliografske baze podataka::
- EMBASE (Excerpta Medica)
- Medline
- Science Citation Index Expanded, Scopus
