Naslov
Occurrence of BRAF and RET mutation in thyroid patients

Autori
Gerić, Marko ; Janušić, Renato ; Šarčević, Božena ; Garaj-Vrhovac, Vera

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Final Programme and Abstract Book of the Second Meeting of the Croatian Association for Cancer Research with international participation / - , 2012, 51-51

Skup
Second Meeting of the Croatian Association for Cancer Research with international participation

Mjesto i datum
Zagreb, Hrvatska, 08.11.2012. - 09.11.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Papillary thyroid cancer; Follicular thyroid adenoma; BRAF; RET

Sažetak
Although endocrine cancer in Croatian population represents 2.51% of all cancers, in the few recent years constant increase of incidence was observed. Among cancers of endocrine system, the cancer of thyroid gland is the most frequent. In present study, the aim was to investigate occurrence of BRAF and RET mutations in patients suffering from thyroid illness. The 20 patients were divided into three groups: (1) Papillary thyroid cancer (PTC), (2) Follicular thyroid adenoma (FTA), and (3) other thyroid diseases (Hashimoto, thyreoiditis) patients. Mean age for PTC group was 48.8 years, consisted of 5 volunteers. FTA group mean age was 50.5 years and consisted of 10 volunteers, while the last group mean age was 51.4 years and consisted of 5 volunteers. After analysis of antibody labeled tissue, results showed that all patients had increased levels of either BRAF or RET proteins. PTC patients had 2 positive BRAF and 2 positive RET mutations, while one patient had positive results for both proteins tested. FTA patients, on the other hand, had 2 positive BRAF and 8 positive RET mutations, while patients with other diseases similarly had 4 positive RET and 1 positive both RET and BRAF mutation. Taken together most patients have only one mutated upstream protein which can then activate one of the downstream MAPK pathways. There is possibility that BRAF is under direct control of RET receptor and that is why there is not so many both RET and BRAF mutations.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

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