Naslov
Antisolvent addition method in batch cooling crystallization of glycine

Autori
Hrkovac, Martina ; Prlić Kardum, Jasna

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
BIWIC 2013 20th International Workshop on Industrial Crystallization / Qu, Haiyan ; Rantanen, Jukka ; Malwade, Chandrakant - Odense : University of Southern Denmark, 2013, 160-167

ISBN
978-87-92646-73-6

Skup
20th International Workshop on Industrial Crystallization, BIWIC 2013

Mjesto i datum
Odense, Danska, 18.09.2013. - 20.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
antisolvent crystallization; glycine; crystal size distribution; polymorphism

Sažetak
Polymorphic crystallization is affected by adding different admixtures, and for many organic compounds, crystallization of polymorphs from solutions with different solvents can influence both the structure and crystal morphology. However, carring out the antisolvent crystallization depends of the selected operating conditions and on the way of manipulating the process. The purpose of this study was to examine the impact of the amount of ethanol on the metastable zone width, supersaturation level, granulometric properties and crystal structure of glycine in the batch cooling crystallization from a mixture of solvents in different amounts. Besides, the objective of this paper is to address how to control the batch antisolvent crystallization process to produce crystals of desired quality. However, the efficiency of such processes strongly depends upon the way of its control. Thus, process was controlled at two different ways. In the first one, the mixture of water – ethanol with appropriate amount of glycine was prepared, and cooling of solution started at the saturation temperature. In the second case, saturated aqueous solution of glycine was prepared, and ethanol was added at defined temperature within metastable zone of pure glycine. The way of manipulating the process has much more impact in relation to the amount of added ethanol on process conditions, and consequently on the granulometric properties of crystals. X - ray analysis indicates formation of α glycine structure regardless of amount of added ethanol or the way of controlling the experiment. This way of experimental approach established a production method of the glycine crystals of desired granulometric properties, which are favourable for further downstream processes.

Izvorni jezik
Engleski

Znanstvena područja
Kemijsko inženjerstvo

POVEZANOST RADA