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Pregled bibliografske jedinice broj: 645019

Ser310Ala functional polymorphism in the GluR7 glutamate receptor subunit gene and alcohol dependence


Kuzman, Boris; Morić, Marina; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Nenadić Šviglin, Korona; Muck-Šeler, Dorotea; Pivac, Nela; Švob Štrac, Dubravka
Ser310Ala functional polymorphism in the GluR7 glutamate receptor subunit gene and alcohol dependence // Book of abstracts / Sinapsa Neuroscience Conference ‘13, Ljubljana, Slovenia, September 27-29, 2013 / Jeran, Judita ; Koritnik, Blaž (ur.).
Ljubljana: Slovenian Neuroscience Association (SiNAPSA), 2013. str. 90-90 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 645019 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Ser310Ala functional polymorphism in the GluR7 glutamate receptor subunit gene and alcohol dependence

Autori
Kuzman, Boris ; Morić, Marina ; Nedić Erjavec, Gordana ; Nikolac Perković, Matea ; Nenadić Šviglin, Korona ; Muck-Šeler, Dorotea ; Pivac, Nela ; Švob Štrac, Dubravka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of abstracts / Sinapsa Neuroscience Conference ‘13, Ljubljana, Slovenia, September 27-29, 2013 / Jeran, Judita ; Koritnik, Blaž - Ljubljana : Slovenian Neuroscience Association (SiNAPSA), 2013, 90-90

ISBN
978-961-91704-5-8

Skup
Sinapsa Neuroscience Conference

Mjesto i datum
Ljubljana, Slovenija, 27.09.2013. - 29.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
alcoholism; alcoholism-related phenotypes; GRIK3 gene; polymorphism; glutamate

Sažetak
Glutamate receptors, the major excitatory neurotransmitter receptors in the brain, have been implicated in acute and chronic effects of alcohol, including alcohol dependence and withdrawal. Kainate ionotropic glutamate receptors have emerged in recent years as important targets of alcohol’s action in the central nervous system. The GRIK3 gene, encoding GluR7 subunit of kainate receptors, is localized on chromosome 1, close to a region associated with alcoholism and alcoholism-related phenotypes. However, diverse results obtained regarding the association of GRIK3 gene with alcoholism might be due to the heterogeneity in alcoholism etiology and phenotype characteristics. Hence, the aim of this study was to investigate the role of the GRIK3 functional polymorphism in patients with alcoholism subdivided according to early/late onset of alcohol abuse, the presence/absence of aggressive behavior and suicide attempts. Genotyping of Ser310Ala polymorphism (rs6691840) in the GRIK3 gene was performed in 275 alcohol-dependent patients of both genders and different smoking status, by using TaqMan Real-Time allelic discrimination after DNA extraction from the blood. The distribution of genotypes and alleles did not differ significantly in alcohol-dependent patients stratified by gender, smoking status, aggressive behavior or suicide attempts. However, the results demonstrated that alcohol-dependent patients with late onset had a higher frequency of a homozygous CC genotype than patients with the early onset of alcohol abuse often reflecting greater alcoholism severity, higher risk for recurrence, as well as comorbid antisocial personality disorder and conduct disorder. Additional studies are needed to further investigate the role of GRIK3 gene in the development of alcoholism.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
098-0000000-2448 - Stres, GABA-A receptori i mehanizmi djelovanja neuropsihofarmaka (Švob Štrac, Dubravka, MZOS ) ( CroRIS)
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Klinika za psihijatriju Vrapče


Citiraj ovu publikaciju:

Kuzman, Boris; Morić, Marina; Nedić Erjavec, Gordana; Nikolac Perković, Matea; Nenadić Šviglin, Korona; Muck-Šeler, Dorotea; Pivac, Nela; Švob Štrac, Dubravka
Ser310Ala functional polymorphism in the GluR7 glutamate receptor subunit gene and alcohol dependence // Book of abstracts / Sinapsa Neuroscience Conference ‘13, Ljubljana, Slovenia, September 27-29, 2013 / Jeran, Judita ; Koritnik, Blaž (ur.).
Ljubljana: Slovenian Neuroscience Association (SiNAPSA), 2013. str. 90-90 (poster, međunarodna recenzija, sažetak, znanstveni)
Kuzman, B., Morić, M., Nedić Erjavec, G., Nikolac Perković, M., Nenadić Šviglin, K., Muck-Šeler, D., Pivac, N. & Švob Štrac, D. (2013) Ser310Ala functional polymorphism in the GluR7 glutamate receptor subunit gene and alcohol dependence. U: Jeran, J. & Koritnik, B. (ur.)Book of abstracts / Sinapsa Neuroscience Conference ‘13, Ljubljana, Slovenia, September 27-29, 2013.
@article{article, author = {Kuzman, Boris and Mori\'{c}, Marina and Nedi\'{c} Erjavec, Gordana and Nikolac Perkovi\'{c}, Matea and Nenadi\'{c} \v{S}viglin, Korona and Muck-\v{S}eler, Dorotea and Pivac, Nela and \v{S}vob \v{S}trac, Dubravka}, year = {2013}, pages = {90-90}, keywords = {alcoholism, alcoholism-related phenotypes, GRIK3 gene, polymorphism, glutamate}, isbn = {978-961-91704-5-8}, title = {Ser310Ala functional polymorphism in the GluR7 glutamate receptor subunit gene and alcohol dependence}, keyword = {alcoholism, alcoholism-related phenotypes, GRIK3 gene, polymorphism, glutamate}, publisher = {Slovenian Neuroscience Association (SiNAPSA)}, publisherplace = {Ljubljana, Slovenija} }
@article{article, author = {Kuzman, Boris and Mori\'{c}, Marina and Nedi\'{c} Erjavec, Gordana and Nikolac Perkovi\'{c}, Matea and Nenadi\'{c} \v{S}viglin, Korona and Muck-\v{S}eler, Dorotea and Pivac, Nela and \v{S}vob \v{S}trac, Dubravka}, year = {2013}, pages = {90-90}, keywords = {alcoholism, alcoholism-related phenotypes, GRIK3 gene, polymorphism, glutamate}, isbn = {978-961-91704-5-8}, title = {Ser310Ala functional polymorphism in the GluR7 glutamate receptor subunit gene and alcohol dependence}, keyword = {alcoholism, alcoholism-related phenotypes, GRIK3 gene, polymorphism, glutamate}, publisher = {Slovenian Neuroscience Association (SiNAPSA)}, publisherplace = {Ljubljana, Slovenija} }




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