Naslov
TRACE ELEMENTS DYSHOMEOSTASIS INDUCED BY EXPOSURE OF MICE TO GASOLINE VAPOR AND STRESS

Autori
Milin, Čedomila ; Tota, Marin ; Grebić, Damir ; Jakovac, Hrvoje ; Broznić, Dalibor ; Marinić, Jelena ; Čanadi Jurešić, Gordana ; Radošević-Stašić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Balkan Journal of Clinical Laboratory, XXI, 13, 1 / Danev, Stoyan ; Shipkov, Todor ; Svinarov, Dobrin A - Budva : Balkan Clinical Laboratory Federation (Montenegrian Association), 2013, 148-148

Skup
21st Meeting of Balkan Clinical Laboratory Federation

Mjesto i datum
Budva, Crna Gora, 25.09.2013. - 28.09.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Gasoline inhalation; Stress; Metallothioneins I; Zinc; Copper; Magnesium; Brain; Lungs; Kidney; Liver

Sažetak
To investigate the effects of air pollution related with gasoline/petrochemical industry the expression of metallothionein I (MT-I) mRNA and tissue metals were analyzed in organs of mice, exposed to the gasoline (G) vapor in laboratory conditions. Control groups consisted of intact mice and of those exposed in the metabolic chamber to fresh air. The data obtained by RT-PCR and inductively coupled plasma spectrometry have shown that exposure to G vapor leads to upregulation of MT-I mRNA in organs that receive a strong respiratory and olfactory input or participate in gasoline degradation and elimination (lungs, brain, kidney and liver). Simultaneously, the tissue content of Zn2+ decreased in the brain and the concentration of Cu2+ and Mg2+ in the brain, lungs, kidney and liver (p<0.001). Some of these changes were found also in mice closed in the metabolic chamber, pointing to the involvement of stress-induced mechanisms in the transcriptional regulation of MTs.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA